Laurisa Dohm

Dermal Cell News

Green Cocoon-Derived Sericin Reduces Cellular Damage Caused by Radiation in Human Keratinocytes

[Scientific Reports] Researchers investigated the effects of green cocoon-derived sericin on human keratinocytes using lactate dehydrogenase activity to indicate damage reduction.

Dermal Cell News

Collagen I Protects Human Keratinocytes HaCaT against UVB Injury via Restoring PINK1/Parkin-Mediated Mitophagy

[Archives Of Biochemistry And Biophysics] Cells grown on plates coated by molecular collagen I, but not fibrillar collagen I, acquired certain resistance against UVB damages, as shown by increased survival and reduced apoptosis.

Dermal Cell News

ANKRD1 Is a Mesenchymal-Specific Driver of Cancer-Associated Fibroblast Activation Bridging Androgen Receptor Loss to AP-1 Activation

[Nature Communications] Investigators identified ANKRD1 as a mesenchymal-specific transcriptional coregulator under direct androgen receptor negative control in human dermal fibroblasts and a key driver of cancer-associated fibroblasts conversion, independent of cellular senescence.

Dermal Cell News

Saracatinib Inhibits Necroptosis and Ameliorates Psoriatic Inflammation by Targeting MLKL

[Cell Death & Disease] In an imiquimod-induced psoriasis mouse model, saracatinib effectively blocked mixed lineage kinase domain-like protein (MLKL) phosphorylation and inflammatory responses in vivo.

Dermal Cell News

Differential Histone Acetylation and Super-Enhancer Regulation Underlie Melanoma Cell Dedifferentiation

[JCI Insight] Scientists identified ITGA3 gene as marked by a super-enhancer element in the Epgn3 invasive cells. Silencing of ITGA3 enhanced invasiveness in both in vitro and in vivo systems suggesting it as a negative regulator of invasion.

Dermal Cell News

Nuclear Mechanotransduction on Skin Stem Cell Fate Regulation

[Current Opinion In Cell Biology] Scientists focus on the key cytoplasmic and nuclear mechanosensitive structures that are critical for the mammalian skin development and homeostatic maintenance.

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A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity Against Prostate Cancer

[Cancer Immunology Research] Scientists reported that the prostate-specific membrane antigen (PSMA) Tri-specific Killer Engager specifically bound to PSMA-expressing cells and significantly enhanced expansion, degranulation, and cytokine production of NK cells derived from healthy donors or prostate cancer patients.

Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer

[Advanced Science] Researchers demonstrated that under enzalutamide treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affected surrounding prostate cancer cells, promoting tumor cell proliferation and anti-androgen resistance.

Rapid Modulation of Striatal Cholinergic Interneurons and Dopamine Release by Satellite Astrocytes

[Nature Communications] Scientists discovered that striatal astrocytes occupied a cell type-specific anatomical and functional relationship with cholinergic interneurons (ChIs), through which they rapidly excited ChIs and governed dopamine release via nicotinic acetylcholine receptors on subsecond timescales.

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Laurisa Dohm

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