 | | Vol. 11.44 – 7 December, 2022 |
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| A population of cancer-associated fibroblasts was induced by interferon signaling and conferred stemness to bladder cancer cells via the WNT5A paracrine pathway.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that insulin/insulin-like growth factor (IGF) signaling supported breast CSC self-renewal in an IRS2-phosphatidylinositol 3-kinase (PI3K)-dependent manner that involved the activation and stabilization of MYC.
[Cell Reports] |
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| Neuropilin-1 receptor (NRP1) inhibition with a novel peptidomimetic agent, MR438, was evaluated with radiotherapy in medulloblastoma models in vitro on cancer stem-like cells as well as in vivo on heterotopic and orthotopic xenografts.
[Cancer Cell International] |
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| Cell lines and clinical specimen-based findings demonstrated that RhoC regulated tumor phenotypes such as clonogenicity and anoikis resistance.
[Cellular and Molecular Life Sciences] |
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| Researchers provided new insights into the interaction between matrix stiffness, cancer cell stemness, and heterogeneity, while also providing a novel hepatocellular carcinoma therapeutic strategy.
[Journal of Translational Medicine] |
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| Investigators utilized paraffin‑embedded sections of human esophageal carcinoma and indicated that the ALDH1‑labeled esophageal CSCs expressed CD14 and primary CD14+ cells possessed the characteristics of CSCs.
[Oncology Reports] |
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| Scientists collected 3D non-adherent spheres as the CSC model to measure lncRNA TDRG1 level in lung CSC and the parental lung cancer cells, and found that TDRG1 level was significantly upregulated in lung CSCs compared to that of parental lung cancer cells
[Environmental Toxicology] |
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| Researchers provided a new insight into tobacco smoke promoting the progression of gastric cancer, demonstrating that tobacco smoke-induced exosomes promoted the spheroidizing ability, stemness genes expression, and epithelial-mesenchymal transition process of gastric cancer stem cells.
[Medical Oncology] |
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| In breast cancer, metastatic tumor cells have higher stem cell properties, therefore the authors evaluated the expression of cicBIRC6 in these cells.
[Molecular Biology Reports] |
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| Cyanidin significantly reduced the cell viability of all glioma stem cells, and exhibited the most substantial effect in GBM2 but no apparent effect in 293T cells.
[International Journal of Neuroscience] |
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| The authors discuss how cell-intrinsic factors, such as the cell of origin or transforming oncogene, and cell-extrinsic factors, such as local nutrient availability, promote or restrain tumour initiation.
[Nature Reviews Endocrinology] |
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| In light of the recently established characterization of primed stem cells in development, scientists propose that CSCs also need to undergo priming before their transition to various progeny phenotypes.
[Cancer and Metastasis Reviews] |
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| Investigators highlight the molecular mechanisms useful for expanding therapeutic strategies based on modulating redox regulation and autophagy activation to targets.
[Clinical and Experimental Medicine] |
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| Personalis, Inc. announced a collaboration with UC San Francisco (UCSF) that will deploy a personalized liquid biopsy-based research use-only assay for a study of patients with colorectal cancer.
[Personalis, Inc.] |
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| January 23 – 25, 2023
Austin, Texas, United States |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany |
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| | Medpace – Remote, Austria |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Bristol Myers Squibb – Uxbridge, England, United Kingdom |
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