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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Acinar to β-Like Cell Conversion through Inhibition of Focal Adhesion Kinase
[Nature Communications] Using lineage tracing studies along with transcriptomic characterization, scientists demonstrated that treatment of adult mice with a small molecule that inhibits kinase activity of focal adhesion kinase resulted in trans-differentiation of a subset of peri-islet acinar cells into insulin producing β-like cells.
Adenosine Kinase Inhibits β-Cell Proliferation by Upregulating DNA Methyltransferase 3A Expression
[Diabetes Obesity & Metabolism] Genetic animal models and transgenic immortalized cells were applied to study the effect of adenosine kinase on islet beta-cell proliferation and function.
Pancreactic Cancer: Succesful Trial against Pancreatic Cancer with Defence’s Arm-002 Anti-cancer Vaccine
[Defence Therapeutics, Inc.] Defence Therapeutics, Inc. announce the completion of a pre-clinical vaccination trial using its ARM-002TM vaccine against pancreatic cancer. The vaccine was shown to be therapeutically effective against pre-established pancreatic cancer especially when combined with the anti-PD-1 immune-checkpoint inhibitor.
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer
[Cancer Research] Scientists investigated the vascular microenvironment of PDAC by applying imaging mass cytometry using a 26-antibody panel on 35 regions of interest across nine patients, capturing over 140,000 single cells.
Galectin-3 Impairs Calcium Transients and β-Cell Function
[Nature Communications] The authors reported that galectin-3, mainly produced and secreted by macrophages, was elevated in islets from both high-fat diet-fed and diabetic mice.
Pancreatic Beta-Cell Mass and Function and Therapeutic Implications of Using Antidiabetic Medications in Type 2 Diabetes
[Journal Of Diabetes Investigation] The authors outline the processes of β-cell failure and detail the many β-cell abnormalities that manifest in people with diabetes mellitus.
Patient-Derived Organoids of Pancreatic Ductal Adenocarcinoma for Subtype Determination and Clinical Outcome Prediction
[Journal Of Gastroenterology] Researchers established patient-derived organoids for pancreatic ductal adenocarcinoma and evaluated their application in subtype classification and clinical outcome prediction.
Glutamine-Mediated Epigenetic Regulation of cFLIP Underlies Resistance to TRAIL in Pancreatic Cancer
[Experimental & Molecular Medicine] Investigators demonstrated that glutamine endowed PDAC cells with resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through KDM4C-mediated epigenetic regulation of cFLIP.
B-Glycine as a Marker for β Cell Imaging and β Cell Mass Evaluation
[European Journal Of Nuclear Medicine And Molecular Imaging] Researchers reported a non-invasive and quantitative imaging technique by using radiolabeled glycine mimics to assay islet function and monitor β cell mass changes in living animals.
Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer
[Cancer Research] To provide insights into the molecular mechanisms regulating IL1A expression in PDAC, researchers performed transcriptional profiling of The Cancer Genome Atlas datasets and pharmacologic screening in PDAC cells and identified p38α MAPK as a key positive regulator of IL1A expression.
From Stem Cells to Pancreatic β-Cells: Strategies, Applications, and Potential Treatments for Diabetes
[Molecular And Cellular Biochemistry] Scientists introduce the development of functional β-cells and their heterogeneity and then turn to highlight recent advances in the generation of β-cells from stem cells and their potential applications in disease modeling, drug discovery and clinical therapy.
FGF7 Enhances the Expression of ACE2 in Human Islet Organoids Aggravating SARS-CoV-2 Infection
[Signal Transduction And Targeted Therapy] Researchers utilized islet organoids derived from human embryonic stem cells, animal models, and COVID-19 patients to discover that fibroblast growth factor 7 (FGF7) enhanced ACE2 expression within the islets, facilitating SARS-CoV-2 infection and resulting in impaired insulin secretion.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
