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Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Kefir-Derived Exopolysaccharide Ameliorates Hyperglycemic Control and Beta Cell Integrity in a Rat Model of Type 2 Diabetes Mellitus
[Nutrition & Diabetes] Scientists assessed the efficacy of kefir-derived exopolysaccharides in ameliorating T2DM in rats induced by streptozotocin and a high-fat diet.
STN1 Facilitates Metastasis by Promoting Transcription of EMT-Activator ZEB1 in Pancreatic Cancer
[Nature Communications] Utilizing multiple PDAC experimental models, researchers discovered STN1’s role in promoting metastasis by functioning as an upstream factor in epithelial-mesenchymal transition.
ER-Phagy and Proteostasis Defects Prime Pancreatic Epithelial State Changes in KRAS-Mediated Oncogenesis
[Developmental Cell] Scientists revealed that an early, transcriptionally mediated effect of Kras is sporadic failure of proteostatic endoplasmic reticulum (ER)-phagy.
Quercetin Alleviates Acute Pancreatitis by Modulating Glycolysis and Mitochondrial Function via PFKFB3 Inhibition
[Cellular and Molecular Life Sciences] Researchers conducted homology analysis of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) protein and identified quercetin as a potential inhibitor through molecular docking.
A CD147-Targeted Small-Molecule Inhibitor Potentiates Gemcitabine Efficacy by Triggering Ferroptosis in Pancreatic Ductal Adenocarcinoma
[Cell Reports Medicine] Scientists identified dracorhodin perchlorate as a potent CD147 inhibitor that induces autophagy-dependent degradation.
Zai Lab Announces China National Medical Products Administration Grants Innovative Medical Device Designation for Tumor Treating Fields for Patients with Pancreatic Cancer
[Zai Lab Limited] Zai Lab Limited announced that the China National Medical Products Administration has granted Innovative Medical Device Designation for Tumor Treating Fields for patients with pancreatic cancer based on the positive results from the Phase III PANOVA-3 trial.
Dynamic GLUT Trafficking at High Glucose Levels Enhances Insulin Secretion: Dysregulation Leads to Decreased Insulin Secretion during Type 2 Diabetes
[Proceedings of The National Academy of Sciences of The United States of America] Investigators uncovered a novel mechanism of glucose transporter (GLUT) trafficking in β cells, highlighting their dynamic response to elevated glucose.
The Insulin Signaling Network
[Nature Metabolism] Investigators examine the architecture of insulin signalling, focusing on its precise temporal regulation.
A Pancreatic Cancer Organoid Biobank Links Multi-Omics Signatures to Therapeutic Response and Clinical Evaluation of Statin Combination Therapy
[Cell Stem Cell] Researchers established 260 pancreatic cancer organoid lines, followed by extensive multi-omics profiling and therapeutic sensitivity assessments.
Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress
[Diabetes] Scientists subjected human islets to overnutrition with 25 mmol/L glucose and 0.5 mmol/L palmitic acid or to a control culture condition with 5.1 mmol/L glucose.
Tumor-Associated Schwann Cell Remodeling under Metabolic Stress via Lactate Sensing Orchestrates Pancreatic Ductal Adenocarcinoma Development
[Cell Metabolism] The authors identified lactate-driven remodeling of tumor-associated Schwann cells as a key mediator of immunosuppression in diabetic PDAC.
The Kinase ERK Plays a Conserved Dominant Role in the Heterogeneity of Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells
[Science Signaling] To understand epithelial-mesenchymal transition heterogeneity at a signaling protein level, investigators combined iterative indirect immunofluorescence imaging of pancreas cancer cells and tumors and mutual information analysis.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
