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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
A Combined Enteric Neuron-Gastric Tumor Organoid Reveals Metabolic Vulnerabilities in Gastric Cancer
[Cell Stem Cell] Researchers highlighted the critical roles of organoid environment and neuronal interaction in cancer lipid reliance.
Human Myelinated Brain Organoids with Integrated Microglia As a Model for Myelin Repair and Remyelinating Therapies
[Science Translational Medicine] Researchers created a human brain organoid comprising neurons, astrocytes, and myelinating oligodendrocytes.
Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis
[Advanced Science] An encapsulation approach was devised in which human brain microvascular endothelial cells are delivered to developing cerebral organoids from progressively degrading extracellular matrix-based hydrogel droplets.
Robotic Micromanipulation for Patterned and Complex Organoid Biofabrication
[Science Advances] Scientists introduced a micromanipulation platform that effectively constrains cell distribution to enable patterned and complex organoid biofabrication.
Controlling Intestinal Organoid Polarity Using Synthetic Dynamic Hydrogels Decorated with Laminin-Derived IKVAV Peptides
[Advanced Healthcare Materials] Scientists demonstrated the essential role of the IKVAV motif in guiding intestinal organoid polarity in synthetic dynamic hydrogels – paving the way for the future design of synthetic systems to culture complex living tissue.
Induction of Nephron-Ductal Dual Lineages via Early Retinoic Acid Signaling Establishes a Platform for Fully Patterned Kidney Organoids
[Advanced Healthcare Materials] Investigators introduce a novel differentiation protocol that eliminates the need for ureteruc bud co-culture and supports the formation of kidney organoids containing complete nephron segments.
Taurine Suppresses aβ Aggregation and Attenuates Alzheimer’s Disease Pathologies in 5XFAD Mice and Patient-Derived Cerebral Organoids
[Biomedicine & Pharmacotherapy] Investigators found that in cerebral organoids derived from an Alzheimer’s disease patient carrying the APOE ε4/ε4 genotype, taurine treatment attenuated Aβ accumulation, decreased tau phosphorylation.
Patient-Derived Organoids from Multiple Sites of a Single Tumor Recapitulates Intratumoral Heterogeneity in Patients with Gastric Cancer
[Gut and Liver] Intratumoral heterogeneity poses challenges for patient-derived organoids (PDO)-based models, highlighting the need for comprehensive assessment. Despite their limitations, PDOs offer valuable insights into precision medicine for patients with gastric cancer, aiding in the development of therapeutic strategies.
Enhanced Electrophysiological Recordings in Acute Brain Slices, Spheroids, and Organoids Using 3D High-Density Multielectrode Arrays
[PloS One] The efficiency of the tissue-sensor interface provided by advanced 3D high-density multi-electrode array technology was evaluated in acute brain slices, spheroids, and organoids obtained from different brain regions.
FibroBiologics Announces Significant Advancements in Bone Marrow Organoid Platform Enabling Development for Cancer and Immune-Related Therapies
[FibroBiologics, Inc.] FibroBiologics, Inc. announced significant advancements in its Bone Marrow Organoid platform, which may offer promising new treatment options for hematopoietic cancers and age-related immune decline.
Organoids As Models of Immune-Organ Interaction
[Cell Reports] In this review, the authors detail how immune-organoid co-cultures can model mucosal immunity at each stage of a functional inflammatory response.
Modeling of T Cell-Mediated Autoimmune Pituitary Disease Using Human Induced Pluripotent Stem Cell-Originated Organoid
[Nature Communications] Scientists employed iPSCs to generate pituitary organoids harboring the patients’ human leukocyte antigen haplotype and coculture the organoids with pituitary-specific transcription factor-1-reactive cytotoxic T cells isolated from the patients’ peripheral blood mononuclear cells.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
