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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Quantifying Y Chromosome Loss in Primary and Metastatic Prostate Cancer by Chromosome Painting
Researchers developed a system to quantify Y chromosome gain or loss in patient-derived prostate cancer organoids. Using this system, they observed Y chromosome loss...
Vitamin D Opposes Multilineage Cell Differentiation Induced by Notch Inhibition and BMP4 Pathway Activation in Human Colon Organoids
[Cell Death & Disease] Investigators reported a differentiation system toward enterocytes and goblet cells, the two major colonic epithelial cell lineages, using colon organoids generated from healthy tissue of colorectal cancer patients.
Identification of Genes that Promote PI3K Pathway Activation and Prostate Tumour Formation
[Oncogene] Using prostate organoid models, scientists showed that either Bzw2 downregulation or EIF5A2 overexpression leads to increased organoid size and in vivo prostate growth.
In Utero and Postnatal Ivacaftor/Lumacaftor Therapy Rescues Multiorgan Disease in CFTR-F508del Ferrets
[JCI Insight] Using primary intestinal organoids and air-liquid interface cultures of airway epithelia, scientists demonstrated that the F508del mutation in ferret CF transmembrane conductance regulator (CFTR) results in a severe folding and trafficking defect, which could be partially restored by treatment with CFTR modulators.
SF3B3-Regulated mTOR Alternative Splicing Promotes Colorectal Cancer Progression and Metastasis
[Journal Of Experimental & Clinical Cancer Research] Colorectal cancer (CRC) cell xenografts, patient-derived xenografts, patient-derived organoids, and orthotopic metastasis mouse models were utilized to determine the in vivo role of SF3B3 in CRC progression and metastasis.
Modeling Acute Myocardial Infarction and Cardiac Fibrosis Using Human Induced Pluripotent Stem Cell-Derived Multi-Cellular Heart Organoids
[Cell Death & Disease] Scientists generated self-organizing heart organoids using human-induced pluripotent stem cells. These organoids consisted of cardiomyocytes, fibroblasts, and endothelial cells, mimicking the cellular composition of the human heart.
Induced Pluripotent Stem Cells (iPSCs): Molecular Mechanisms of Induction and Applications
[Signal Transduction And Targeted Therapy] The authors outline key developments in the induced pluripotent stem cell (iPSC) field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications.
New TEC Organoid Model to Study Thymus Function
[Drug Target Review] Scientists at the Organoid group have developed a new organoid model derived from thymic epithelial cells (TECs) that can be used to study the thymus. This is the first laboratory model that enables long-term culture of TECs, presenting new opportunities to study their function.
Patient-Derived Organoids of Pancreatic Ductal Adenocarcinoma for Subtype Determination and Clinical Outcome Prediction
[Journal Of Gastroenterology] Researchers established patient-derived organoids for pancreatic ductal adenocarcinoma and evaluated their application in subtype classification and clinical outcome prediction.
Sclareol Protected against Intestinal Barrier Dysfunction Ameliorating Crohn’s Disease-Like Colitis via Nrf2/NF-B/MLCK Signaling
[International Immunopharmacology] In vitro, a TNF-α-induced colonic organoid model was established to test the direct effect of sclareol on inflammation-induced intestinal barrier injury and inflammatory response. The Nrf2/NF-κB/MLCK signaling was analyzed to explore the mechanism of sclareo.
Vitamin D Opposes Multilineage Cell Differentiation Induced by Notch Inhibition and BMP4 Pathway Activation in Human Colon Organoids
[Cell Death & Disease] Scientists reported a differentiation system toward enterocytes and goblet cells, the two major colonic epithelial cell lineages, using colon organoids generated from healthy tissue of colorectal cancer patients.
Endogenous Mutant Huntingtin Alters the Corticogenesis via Lowering Golgi Recruiting ARF1 in Cortical Organoid
[Molecular Psychiatry] Scientists replicated the altered corticogenesis in the Huntington's disease (HD) fetal brain using HD patient-derived human cortical organoids (hCOs). Our HD-hCOs had pathological phenotypes, including deficient junctional complexes in the neural tubes, delayed postmitotic neuronal maturation, dysregulated fate specification of cortical neuron subtypes, and abnormalities in early HD subcortical projections during corticogenesis.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
