Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Disease Related Changes in ATAC-Seq of iPSC-Derived Motor Neuron Lines from ALS Patients and Controls

May 2, 2024

[Nature Communications] Scientists examined the epigenomic profiles of more than 500 cell cultures of iPSC-derived motor neurons generated from ALS patients and healthy controls to test for the presence of genetically driven, disease-relevant changes in chromatin accessibility and dysregulated transcriptional programs.

A Positive Feedback Inhibition of Isocitrate Dehydrogenase 3β on Paired-Box Gene 6 Promotes Alzheimer-Like Pathology

May 2, 2024

[Signal Transduction And Targeted Therapy] Scientists reported a substantial decline in isocitrate dehydrogenase 3β (IDH3β) levels, a critical tricarboxylic acid cycle enzyme, in Alzheimer's disease (AD) patients and AD-transgenic mouse brains.

New Perspective on Sustained Antidepressant Effect: Focus on Neurexins Regulating Synaptic Plasticity

May 2, 2024

[Cell Death Discovery] Using neurexins as a starting point, the current research findings on the effects of neurexins transsynaptic complexes on synaptic plasticity are summarized and their use as a potential new perspective for sustained antidepressant effect is discussed.

Anova to Manage Study of DB107 Following Newly Awarded $11.8M CIRM Grant

May 1, 2024

[Anova Enterprises, Inc.] Anova Enterprises, Inc. has collaborated with University of California at San Francisco, University of California at San Diego, University of Southern California, and Denovo Biopharma to manage a newly awarded $11.8M California Institute for Regenerative Medicine (CIRM) grant to support the development of DB107 in patients with newly diagnosed high-grade glioma.

Harnessing Nanochaperone-Mediated Autophagy for Selective Clearance of Pathogenic Tau Protein in Alzheimer’s Disease

May 1, 2024

[Advanced Materials] Investigators developed pathogenic tau-specific autophagy based on customized nanochaperone for Alzheimer’s disease treatment.

D-Peptide-Magnetic Nanoparticles Fragment Tau Fibrils and Rescue Behavioral Deficits in a Mouse Model of Alzheimer’s Disease

May 1, 2024

[Science Advances] Scientists designed a seven-residue D-TLKIVWC peptide, which not only prevented tau aggregation but also fragmented tau fibrils extracted from Alzheimer’s disease brains to neutralize their seeding ability and protect neuronal cells from tau-induced toxicity.

PARKIN is Not Required to Sustain OXPHOS Function in Adult Mammalian Tissues

April 30, 2024

[npj Parkinson's Disease] Researchers investigated the mitochondrial role of PARKIN during aging and in response to stress by employing a series of conditional Parkin knockout mice.

Origin, Identity, and Function of Terminal Schwann Cells

April 29, 2024

[Trends In Neurosciences] The authors summarize the state-of-knowledge about each terminal Schwann cells (TSC) type and explore the opportunities that TSCs provide to treat conditions that afflict peripheral axon terminals.

BRG1 Programs PRC2-Complex Repression and Controls Oligodendrocyte Differentiation and Remyelination

April 26, 2024

[Journal of Cell Biology] Scientists demonstrated that Brg1 loss profoundly impaired oligodendrocyte-precursor cell (OPC) differentiation in the brain with a comparatively lesser effect in the spinal cord. Moreover, BRG1 was critical for OPC remyelination after injury.

Dual-Targeted Novel Temozolomide Nanocapsules Encapsulating siPKM2 Inhibit Aerobic Glycolysis to Sensitize Glioblastoma to Chemotherapy

April 26, 2024

[Advanced Materials] To effectively inhibit aerobic glycolysis, increase drug delivery efficiency, and improve drug sensitivity, researchers successfully designed and prepared a novel TMZ nanocapsule for the combined delivery of siPKM2 and TMZ.

Lineage Specific Transcription Factor Waves Reprogram Neuroblastoma from Self-Renewal to Differentiation

April 24, 2024

[Nature Communications] To identify super-enhancers driving transcription factor regulators, investigators used all-trans retinoic acid to induce neuroblastoma growth arrest and differentiation.

Endogenous Mutant Huntingtin Alters the Corticogenesis via Lowering Golgi Recruiting ARF1 in Cortical Organoid

April 24, 2024

[Molecular Psychiatry] The authors replicated the altered corticogenesis in the Huntington’s disease (HD) fetal brain using HD patient-derived human cortical organoids.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.