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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
A Novel Preclinical Model of the Normal Human Breast
[Journal Of Mammary Gland Biology And Neoplasia] Investigators described a normal breast explant model utilising a tuneable hydrogel which maintained epithelial proliferation, hormone receptor expression, and residency of T cells and macrophages over seven days.
Synergistic Effects of miR-143 with miR-99a Inhibited Cell Proliferation and Induced Apoptosis in Breast Cancer
[Biotechnology and Applied Biochemistry] The authors investigated the effects of miR-99a and miR-143 in single expression plasmids for breast cancer (BC) inhibition. Upregulation of miR-99a and miR-143 in any of the two selected BC cells inhibited their proliferation and migration rate, and induced apoptosis.
Loss of Tumor-Derived SMAD4 Enhances Primary Tumor Growth but Not Metastasis Following BMP4 Signaling
[Cell Communication and Signaling] Using preclinical models of spontaneous breast cancer metastasis, scientists investigated the impact of SMAD4 on the ability of bone morphogenetic protein 4 (BMP4) to regulate tumor growth and metastasis.
Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression
[Cancer Discovery] Scientists identified a subset of myofibroblast cancer-associated fibroblast (CAFs) that were senescent (senCAF) in mouse and human breast tumors. SenCAFs were present in HER2+, ER+, and triple-negative breast cancer and in ductal carcinoma in situ (DCIS) where they predicted tumor recurrence.
Drug Resistance in Breast Cancer is Based on the Mechanism of Exocrine Non-Coding RNA
[Discover Oncology] The authors provide insights into the mechanism of exosome-derived non-coding RNAs (ncRNAs) in breast cancer (BC) drug resistance, thereby suggesting new strategies for the treatment of BC.
Breast Cancer Research Receives Funding Boost
[Monash University] Two research projects on different aspects of breast cancer treatment led by Monash Biomedicine Discovery Institute researchers, Drs. Lan Nguyen and Thierry Jardé have been awarded a total of almost $1.5 milion by the National Breast Cancer Foundation.
IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
[Cancer Research] Scientists observed that interleukin-1 receptor type 2 (IL1R2) blockade strongly attenuated macrophage recruitment and the polarization of tumor-associated macrophages to inhibit breast tumor-initiating cell (BTIC) self-renewal and CD8+ T cell exhaustion, which resulted in reduced tumor burden and prolonged survival in TNBC mouse models.
CARM1 Hypermethylates the NuRD Chromatin Remodeling Complex to Promote Cell Cycle Gene Expression and Breast Cancer Development
[Nucleic Acids Research] Scientists revealed a gene activation program that required arginine methylation established by coactivator-associated arginine methyltransferase 1 (CARM1) on a key chromatin remodeler.
miR-192 Family in Breast Cancer: Regulatory Mechanisms and Diagnostic Value
[Biomedicine & Pharmacotherapy] The authors describe the regulatory mechanism of the miRNA-192 family affecting the malignant behavior of breast cancer cells and evaluate the value of the miRNA-192 family as a diagnostic and prognostic biomarker for breast cancer.
Evexta Bio Reports Progress towards Clinical Development of Rupitasertib in Advanced Breast Cancer
[Evexta Bio SA] Evexta Bio SA provided an update on the clinical development of its lead asset, rupitasertib, a selective oral inhibitor of S6K and AKT1/AKT3.
Chemotherapy-Elicited Extracellular Vesicle CXCL1 From Dying Cells Promotes Triple-Negative Breast Cancer Metastasis by Activating TAM/PD-L1 Signaling
[Journal Of Experimental & Clinical Cancer Research] Investigators highlighted CXCL1EV-dead as a novel dying cell-released signal and provided TPCA-1 as a targeting candidate to improve TNBC prognosis.
Toxoplasma gondii Suppresses Proliferation and Migration of Breast Cancer Cells by Regulating Their Transcriptome
[Cancer Cell International] The effect of tachyzoites of T. gondii on human breast cancer cells proliferation and migration was assessed using cell growth curve and wound healing assays.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
