Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Fibrostricturing Crohn’s Disease Is Marked by an Increase in Active Eosinophils in the Deeper Layers

May 1, 2024

[Clinical And Translational Gastroenterology] This study characterized immune cell distribution and protein expression in fibrotic and inflamed ileal tissue of Crohn's disease patients. Immunologic, proteomic and histological data suggest inflammation and fibrosis were intertwined, with large overlap between both tissue types.

Alzheimer’s Disease-Related Presenilins Are Key to Intestinal Epithelial Cell Function and Gut Immune Homoeostasis

April 30, 2024

[Gut] Scientists generated intestinal epithelium-specific Psen1-deficient, Psen2-deficient and inducible Psen1/Psen2 double-deficient mice to dissect the functional role of presenilins in intestinal homoeostasis.

CBX3 Antagonizes IFNγ/STAT1/PD-L1 Axis to Modulate Colon Inflammation and CRC Chemosensitivity

April 30, 2024

[EMBO Molecular Medicine] The authors revealed that the epigenetic regulator, chromobox protein homolog 3 (CBX3) antagonized IFNγ signaling in the colon epithelium by transcriptionally repressing two critical IFNγ-responsive genes: STAT1 and CD274.

Mitochondrial Genome Transfer Drives Metabolic Reprogramming in Adjacent Colonic Epithelial Cells Promoting TGFβ1-Mediated Tumor Progression

April 30, 2024

[Nature Communications] Scientists revealed that intact mitochondrial genome was enriched in serum extracellular vesicles from colon cancer patients and positively correlated with tumor stage.

Vitamin D Opposes Multilineage Cell Differentiation Induced by Notch Inhibition and BMP4 Pathway Activation in Human Colon Organoids

April 29, 2024

[Cell Death & Disease] Scientists reported a differentiation system toward enterocytes and goblet cells, the two major colonic epithelial cell lineages, using colon organoids generated from healthy tissue of colorectal cancer patients.

NAT10-Mediated ac4C Modification Promotes Stemness and Chemoresistance of Colon Cancer by Stabilizing NANOGP8

April 29, 2024

[Heliyon] The levels of NAT10 in normal colon and chemoresistant colon cancer tissues were determined utilizing quantitative real-time polymerase chain reaction alongside immunohistochemistry.

LSD1 Drives Intestinal Epithelial Maturation and Controls Small Intestinal Immune Cell Composition Independent of Microbiota in a Murine Model

April 25, 2024

Scientists showed that intestinal-epithelial intrinsic expression of lysine-specific demethylase 1A (LSD1) was necessary for the postnatal maturation of intestinal epithelium and maintenance of this...

Recent Progress on Engineered Micro/Nanomaterials Mediated Modulation of Gut Microbiota for Treating Inflammatory Bowel Disease

April 25, 2024

[Journal Of Controlled Release] The authors present the interactions among the immune system, intestinal barrier, and gut microbiome. In addition, recent advances in administration routes and methods that positively arouse the regulation of intestinal flora for inflammatory bowel disease using probiotics, prebiotics, and redox-active micro/nanomaterials have been reviewed.

Palisade Bio Successfully Demonstrates Bioactivation of PALI-2108 in Ex-Vivo Study of Normal Healthy and Ulcerative Colitis Patients’ Stool

April 25, 2024

[Palisade Bio, Inc.] Palisade Bio, Inc. announced the successful completion of its analysis evaluating ex-vivo bioactivation of PALI-2108, an orally administered, locally acting colon-specific phosphodiesterase-4 (PDE4) inhibitor prodrug in development for patients affected by ulcerative colitis.

Mulberry Leaf-Derived Morin Activates β-Catenin by Binding to Frizzled7 to Promote Intestinal Stem Cell Expansion Upon Heat-Stable Enterotoxin B Injury

April 24, 2024

[Journal Of Agricultural And Food Chemistry] Investigators revealed an unexpected role of leaf-derived morin, which represents molecular signaling targeting the Frizzled7 (FZD7) platform instrumental for controlling intestinal stem cells regeneration upon stable enterotoxin b injury.

T-Bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells

April 24, 2024

[Advanced Science] The findings unveiled a previously unrecognized role of T-bet in intestinal epithelial cells for inducing apoptosis, diarrhea, and local inflammation, thus implicating its potential as a therapeutic target for the treatment of cancer and inflammatory diseases.

Sirt2 Inhibition Improves Gut Epithelial Barrier Integrity and Protects Mice from Colitis

April 23, 2024

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers established that small-molecule inhibitors of Sirt2 were promising treatment strategies for inflammatory bowel disease. Small-molecule inhibitors of enzymes had been increasingly used to investigate the biological function of enzymes.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.