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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Toripalimab, Bevacizumab, and Irinotecan in dMMR/MSI Locally Advanced Colorectal Cancer: First-Stage Results from a Phase Ib/II Trial
[Cell Reports Medicine] This was the first stage of the Phase Ib/II trial evaluating the effectiveness and safety of toripalimab, irinotecan, and bevacizumab in patients with rectal cancer refusing up-front surgery or radiation therapy and patients with T4NanyM0 colon cancer with deficiency of mismatch repair or microsatellite instability.
The Nα-Acetyl-L-Lysine/Loxl2/H2O2 Promotes Intestinal Tumor Growth in Drosophila and Cell Proliferation in Human Colorectal Cancer
[Cell Reports] Scientists showed that Staphylococcus sciuri promotes Drosophila intestinal tumor growth by inducing intestinal stem cell division.
METTL3 Facilitates Colorectal Cancer Growth through Altering the Abundance of Intestinal Akkermansia muciniphila
[Cancer Gene Therapy] Single-cell sequencing data showed elevated mRNA expression of methyltransferase-like protein 3 (METTL3) in CRC, which is correlated with the abundance of intestinal microbiota.
UBE2C-Mediated Ubiquitination of ACSL4 Inhibits Ferroptosis and Promotes Gastric Cancer Progression
[Discover Oncology] Data from TCGA and GEO datasets revealed significant upregulation of UBE2C in gastric cancer tissues, with a negative correlation between UBE2C and ACSL4, a key regulator of ferroptosis.
Early-Onset Colorectal Cancer As an Emerging Disease of Metabolic Dysregulation
[Nature Reviews Endocrinology] Investigators synthesize evidence on the relationship of obesity and type 2 diabetes mellitus with early-onset CRC, focusing on pathophysiological mechanisms and the mediating roles of diet and lifestyle factors.
Gates Foundation Awards $3 Million in Grants to UMass Chan to Study Gut Health in Pregnant Women in low- and Middle-Income Countries
[UMass Chan Medical School] The Gates Foundation is providing funding to two labs in the Program in Microbiome Dynamics at UMass Chan Medical School for research aimed at improving pregnancy outcomes and gut health in women from low- and middle-income countries.
G Protein-Coupled Receptors: Pivotal Hubs in Gastric Cancer Malignancy-From Multidimensional Crosstalk to Precision Therapeutics
[Journal of Translational Medicine] The authors critically evaluate the translational value of G protein-coupled receptors (GPCRs) as diagnostic indicators and therapeutic targets, summarize current GPCR-targeted strategies, and propose future research directions to advance precision diagnosis and therapeutic management of gastric cancer.
Integrative Multiomics Analysis Reveals the Subtypes and Key Mechanisms of Platinum Resistance in Gastric Cancer: Identification of KLF9 As a Promising Therapeutic Target
[Journal of Translational Medicine] Key genes related to platinum resistance in gastric cancer (GC) were selected from the platinum resistance gene database and GC resistance datasets.
EPS8L2 Drives Colorectal Cancer Cell Proliferation and Migration via YBX1-Dependent Activation of G3BP2 Transcription
[Cell Death & Disease] Investigators identified EPS8L2 as a novel driver of colorectal tumorigenesis. EPS8L2 is significantly upregulated in CRC tissues and negatively correlated with patients’ prognosis.
The Effect of USP17 Knockdown on Autophagic Ferroptosis in Gastric Cancer by Regulating the BNIP3-NCOA4-FTH1 Axis
[Journal of Molecular Histology] Investigators cultured human gastric cancer cell line AGS in vitro and knocked BNIP3 or NCOA4 down using specific small interfering-RNA.
Integrated Transcriptomic and Functional Modeling Reveals AKT and mTOR Synergy in Colorectal Cancer
[Scientific Reports] Researchers developed a drug discovery pipeline using patient-derived primary colorectal cancer cultures with diverse genomic profiles.
Timosaponin AIII Inhibits Gastric Cancer by Causing Oxidative Stress and Blocking Autophagic Flux
[Translational Oncology] MTT assay, cell cycle analysis, and wound healing assay were used to evaluate the inhibitory effects of timosaponin AIII on gastric cancer cells.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
