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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Curcumin for Inflammatory Bowel Disease Therapy: Advances in Mechanisms, Clinical Applications, and Drug Delivery
[Archives of Pharmacal Research] The authors provide a comprehensive overview of recent advances in the mechanistic insights, clinical applications, and drug delivery strategies of curcumin in inflammatory bowel disease therapy, to support future research and clinical translation.
Inhalable Materials and Biologics for Lung Defense and Drug Delivery
[Nature Reviews Materials] The authors thoroughly examine the structure and function of airway mucus, along with the challenges and opportunities it presents for inhaled treatments.
Trethera Receives $1.8 Million NIH Grant to Advance TRE-515 Development for Crohn’s Disease
[Trethera Corporation] Trethera Corporation announced that the National Institutes of Health awarded Trethera a $1.8 million grant for preclinical studies of TRE-515 as a Crohn’s disease treatment.
GPR15 Differentially Regulates the Effects of Cigarette Smoke Exposure on Crohn’s Disease and Ulcerative Colitis
[Signal Transduction and Targeted Therapy] Scientists demonstrated the detrimental impact of cigarette smoke on Crohn’s disease progression while highlighting its beneficial effects on ulcerative colitis, as evidenced by analyses of human sample data.
Creeping Fat-Derived Mechanosensitive Fibroblasts Drive Intestinal Fibrosis in Crohn’s Disease Strictures
[Cell] Investigators identified creeping fat (CF)-derived, CTHRC1+ fibroblasts enriched for Yes-associated protein/transcriptional co-activator with PDZ-binding motif signatures and localized to a fibrotic CF-bowel wall interface within the stricture.
Mechanosensitive Calcium Channels and Integrins Coordinate the Reprogramming of Colorectal Cancer Cells into a Fetal-Like State
[Cell Reports] Using colorectal cancer (CRC) organoid models, researchers demonstrated that mechanical interactions with collagen I, a main constituent of the interstitial matrix, instruct the reprogramming of CRC cells.
Cetuximab Increases LGR5 Expression and Augments LGR5-Targeting Antibody-Drug Conjugate Efficacy in Patient-Derived Colorectal Cancer Models
[Cell Reports Medicine] The authors reported that cetuximab augments leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expression independent of RAS/PIK3CA mutation status and promotes epidermal growth factor receptor (EGFR)-LGR5 interactions.
TRIM21 Promotes Colorectal Cancer Development through Regulating DNA Replication by TCF3/MCM2/5 Axis
[Cell Death Discovery] Researchers found that Tripartite motif containing 21 (TRIM21) was highly expressed in colorectal cancer (CRC) and could be valuable for predicting the prognosis of CRC patients.
Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns
[Aging Cell] Investigators examined the intestine of the very short-lived aging model system, the African turquoise killifish, throughout its lifetime.
Targeted Liposome Garcinol Formulation for the Treatment of Colon Cancer: Pharmacological and Toxicological Evaluation
[ACS Applied Bio Materials] In a murine colon carcinoma model, the targeted liposomal garcinol formulation effectively targeted tumors, activated cell death pathways, and inhibited metastasis.
USP10-Mediated Ku70/80 Stabilization Inhibits PANoptosis and Promotes Chemoresistance in Colorectal Cancer
[Oncogene] Researchers discovered that the expression levels of USP10 increase in tumor cells in response to chemotherapy, contributing to chemotherapy resistance.
Human Gastroids to Model Regional Patterning in Early Stomach Development
[Nature] Scientists reported human gastroids, a self-organized multilineage gastric organoid derived from hPSCs to model gastric fundic-antral patterning in vitro.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
