Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

Subscribe|Follow Us On

CD8+ T Cells Sustain Vaccination-Induced Immunity against Dissemination of Contained Tuberculosis in Immunosuppressed Hosts

March 25, 2026

[Nature Communications] Scientists showed that immunosuppression-induced dissemination of lymphatic Mycobacterium tuberculosis and ensuing progressive disease can be prevented by vaccination with BCG or recombinant BCG even in the absence of CD4+ T cells.

A New mRNA Antigen Vaccine Induces Potent B and T Cell Responses and In Vivo Protection against SARS-CoV-2

March 25, 2026

[NPJ Vaccines] Scientists added new T cell epitopes to the receptor-binding domain RBD mRNA vaccine and identified a SARS-CoV-2 membrane epitope that significantly improved vaccine-induced immunity and protection in vivo.

CD4+ T Cell-Mediated Immunity Protects from VSV-SUD Lethal Challenge in a Mouse Model of Sudan Virus Infection

March 25, 2026

[Nature Immunology] To unravel mechanisms contributing to protection, researchers used a surrogate mouse model of Sudan virus infection amenable to deep functional analysis.

Host Macrophages/Monocytes Promote Malaria Transmission by Modulating Mosquito Microbiota via SR-a-Mediated Phagocytosis

March 25, 2026

[Nature Communications] Researchers demonstrated that macrophages/monocytes—rather than neutrophils or NK/NKT cells—play a crucial role in enhancing malaria transmission to mosquitoes, both in rodent models and human.

Exposed Phosphatidylserine Is an Inhibitory Molecule in T Cell Exhaustion

March 25, 2026

[Nature] Researchers showed that viable, antigen-specific CD8 T cells externalize phosphatidylserine during lymphocytic choriomeningitis virus infection.

Tessera Therapeutics Receives Grant to Advance In Vivo Gene Writing Approaches Towards a Potential Human Immunodeficiency Virus (HIV) Cure

March 25, 2026

[Tessera Therapeutics] Tessera Therapeutics announced that it has received a grant from the Gates Foundation to support early-stage research exploring multiple genetic approaches aimed at developing a scalable cure for HIV.

Global Virus Network Awards Education & Training Grants to Advance Next-Generation Virology Research and Pandemic Preparedness

March 25, 2026

[Global Virus Network ] The Global Virus Network announced the recipients of $90,000 in 2025 Education and Training Grants, supporting emerging scientists and institutions advancing translational virology, genomic surveillance, data-driven preparedness, and global health equity.

Sirtuin2 Blockade Inhibits Replication of Human Immunodeficiency Virus-1 and Mycobacterium Tuberculosis in Macrophages and Humanized Mice

March 25, 2026

[Molecular Therapy] Researchers found that human M1 macrophages inhibit Mycobacterium tuberculosisgrowth, while M2 macrophages, characterized by elevated Sirt2 expression, permit Mtb growth

New $1.9 Million Grant Lets Montana State Team Deepen Understanding of Avian Flu

March 23, 2026

[MSU News Service] Assistant professor Dr. Emma Loveday of the College of Agriculture’s Department of Microbiology and Cell Biology is the lead investigator on a $1.9 million grant awarded by the US Department of Agriculture to study highly pathogenic avian influenza, more commonly known as “bird flu.

Renaissance of Antiviral CD8+ T Cell Immunity in Vaccination and Disease

March 23, 2026

[Nature Reviews Immunology] The authors highlight shared features, such as effector functions and stemness properties, of effective CD8⁺ T cell responses against diverse viruses such as SARS-CoV-2 and HIV.

LRP8 Is a Functional Receptor for Yellow Fever Virus

March 23, 2026

[Nature Microbiology] Scientists showed that LRP8 expression increases yellow fever virus (YFV) infection in cell lines by promoting entry. LRP8 knockdown decreases YFV infection in brain cells, primary human hepatocytes and mosquitoes.

TGF-β Mediates Epigenetic Control of Innate Antiviral Responses and SIV Reservoir Size

March 23, 2026

[Nature Immunology] Researchers provided a framework that features epigenetic programming of myeloid and CD4+ T cells as a major mechanism that promotes decay of the HIV reservoir.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.