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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Epitope-Optimized Vaccine Elicits Enduring Immunity against Swine Influenza A Virus
[Nature Communications] Investigators described the Epigraph, a computationally derived and epitope optimized set of vaccine immunogens.
Porphyromonas gingivali Induces Zbp1-Mediated Macrophages PANoptosis in Periodonitis Pathophysiology
[Experimental & Molecular Medicine] Researchers found that P. gingivalis infection notably activates multiple death pathways in bone-marrow-derived macrophages, including pyroptosis, apoptosis, and necrosis.
Self-Assembly of Nanogold Triplets on Trimeric Viral Proteins for Infectious Disease Diagnosis
[ACS Nano ] Scientists presented the self-assembly of nanogold triplets on trimeric viral surface proteins for a sensitive colorimetric assay to identify viruses.
Clone Tracking through Repeated Malaria Identifies High-Fidelity Memory CD4 T Cell Responses
[Science Immunology] Investigators used longitudinal single-cell RNA and T cell receptor tracking to study the functional stability and memory potential of CD4+ T cell clonotypes during repeated Plasmodium falciparum infections in Ugandan children and adults.
Chimeric Virus-Like Particles of Nodavirus Displaying M2e of Human and Avian Influenza a Viruses As a Potential Dual-Use Vaccine: Inducing a Broader Immune Response...
[Vaccine] Researchers investigated the breadth and cross-subtype immunity of these chimeric cirus-like particles in BALB/c mice to assess their potential for human use.
Engineered Antibody-Mediated Broad-Spectrum Suppression of Human Arboviruses in the Aedes aegypti Vector
[Communications Biology] Scientists explored the use of protective small antibodies for the development of transgenic mosquito-based arboviral disease control strategies.
An Intranasal Subunit Vaccine Induces Protective Systemic and Mucosal Antibody Immunity against Respiratory Viruses in Mouse Models
[Nature Communications] Scientists reported on a subunit vaccine platform, in which the antigen is genetically fused to albumin to facilitate FcRn-mediated transport across the mucosal barrier in the presence of adjuvant.
B Cells Modulate Lung Antiviral Inflammatory Responses via the Neurotransmitter Acetylcholine
[Nature Immunology] The authors reported that B cells are the most prevalent acetylcholine-producing leukocyte population in the respiratory tract demonstrated with choline acetyltransferase-green fluorescent protein reporter mice, both before and after infection with influenza A virus.
Variant Mutation G215C in SARS-CoV-2 Nucleocapsid Enhances Viral Infection via Altered Genomic Encapsidation
[PLOS Biology] Scientists identified a mutation (G215C), characteristic of the Delta variant, that introduces a novel cysteine into this linker domain, which results in the formation of a more stable N-N dimer.
M. tuberculosis Surface Sulfoglycolipid SL-1 Activates the Mechanosensitive Channel TRPV4 to Enhance Lysosomal Biogenesis and Exocytosis in Macrophages
[Molecular Biology of the Cell] Researchers showed that sulfolipid-1 (SL-1) induces calcium influx into macrophages and identified the mechanosensitive calcium channel TRPV4 as a crucial upstream mediator of SL-1–induced lysosomal remodeling.
Genomic Analysis of Progenitors in Viral Infection Implicates Glucocorticoids As Suppressors of Plasmacytoid Dendritic Cell Generation
[Proceedings of The National Academy of Sciences of The United States of America] Investigators characterized the transcriptional and epigenetic landscapes of dendritic cell progenitors after infection.
A Distinctive IGHV3-66 SARS-CoV-2 Neutralizing Antibody Elicited by Primary Infection with an Omicron Variant
[Structure] Scientists reported an IGHV3-66-encoding monoclonal neutralizing antibody (nAb), ConBA-998, that was elicited by primary infection with BA.1. ConBA-998 is an Omicron-dependent nAb with high binding affinity that triggers the shedding of the S1 subunit from the spike protein.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
