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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
HDAC Inhibition Increases CXCL12 Secretion to Recruit Natural Killer Cells in Peripheral T Cell Lymphoma
[Cancer Research] Researchers found that high expression of histone deacetylase (HDAC)3 was associated with poor prognosis in peripheral T cell lymphoma. HDAC3 inhibition suppressed lymphoma growth in immunocompetent mice but not in immunodeficient mice.
LGR6 Frameshift Variant Abrogates Receptor Expression on Select Leukocyte Subsets and Associates With Viral Infections
[Blood] In neutrophils, monocytes, and natural killer cells from volunteers homozygous for this variant, investigators found a significant downregulation in the expression of leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) when compared with controls without the variant.
Fate Therapeutics Announces First Lupus Patient Treated in Phase 1 Autoimmunity Study of Off-the-shelf FT819 CAR T-cell Program
[Fate Therapeutics, Inc.] Fate Therapeutics, Inc. announced that the first patient with systemic lupus erythematosus has been treated in the Phase I autoimmunity study of FT819, the company’s off-the-shelf, CD19-targeted chimeric antigen receptor T cell program.
THEMIS Promotes T Cell Development and Maintenance by Rising the Signaling Threshold of the Inhibitory Receptor BTLA
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that the T cell lineage protein THEMIS operates as a rheostat which restrain the signaling capacity the inhibitory receptor B- and T-lymphocyte attenuator (BTLA).
Triune Nanomodulator Enables Exhausted Cytotoxic T Lymphocyte Rejuvenation for Cancer Epigenetic Immunotherapy
[ACS Nano] Scientists presented a well-designed triune nanomodulator, termed ROCA, which demonstrated robust capabilities in tumor epigenetic modulation and immune microenvironment reprogramming for cancer epigenetic immunotherapy.
The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance
[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, researchers identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.
The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance
[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, investigators identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.
Thymocyte Migration and Emigration
[Immunology Letters] Investigators review the contribution of the key factors mentioned above for the localization, migration and emigration of thymocytes.
Traverse Biotech Awarded Phase I SBIR Grant by the National Institute of Allergy and Infectious Diseases for Development of Innate Immune Stimulator
[Traverse Biotech, Inc. (PR Newswire)] Traverse Biotech, Inc. has been awarded a Phase I Small Business Innovation Research grant from the National Institute of Allergy and Infectious Diseases, part of the NIH.
ABBV-319: A CD19-Targeting Glucocorticoid Receptor Modulator Antibody-Drug Conjugate Therapy for B Cell Malignancies
[Blood] ABBV-319 elicited potent glucocorticoid receptor modulator-driven anti-tumor activity against multiple malignant B cell lines in vitro as well as in cell line-derived xenografts and patient-derived xenografts in vivo.
Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancer Tumors
[Cancer Immunology Research] Scientists showed JHU083-mediated glutamine antagonism in tumor microenvironments induced TNF, pro-inflammatory, and mTORC1 signaling in intratumoral tumor-associated macrophages clusters.
ALOX15+ M2 Macrophages Contribute to Epithelial Remodeling in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
[Journal Of Allergy And Clinical Immunology] Researchers investigated the role of ALOX15+ M2 macrophages in the epithelial remodeling of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). Digital spatial transcriptome and single-cell sequencing analyses were used to characterize the epithelial remodeling and cellular infiltrate in eCRSwNP.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
