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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Urban Indoor Gardening Enhances Immune Regulation and Diversifies Skin Microbiota – a Placebo-Controlled Double-Blinded Intervention Study
[Environment International] Investigators provided evidence in support of the core assumption of the hygiene and biodiversity hypotheses of immune-mediated diseases.
Allergen-Encapsulating Nanoparticles Reprogram Pathogenic Allergen-Specific Th2 Cells to Suppress Food Allergy
[Advanced Healthcare Materials] Scientists investigated the ability of allergen-encapsulating nanoparticles (NPs) to directly suppress pathogenic Th2 responses and reactivity in a mouse model of food allergy. NPs associated with pro-tolerogenic antigen-presenting cells, provoking the accumulation of suppressive regulatory T cells in the small intestine lamina propria.
Suppression of Lysosome Metabolism-Meditated GARP/TGF-β1 Complexes Specifically Depletes Regulatory T Cells to Inhibit Breast Cancer Metastasis
[Oncogene] Researchers demonstrated that tumour necrosis factor receptor-associated factor 3 interacting protein 3 (TRAF3IP3) in the Treg lysosome was involved in the activation mechanism of transforming growth factor-β1.
Treg-Derived Extracellular Vesicles: Roles in Diseases and Theranostics
[Molecular Pharmaceutics] The authors clarified the feasibility and potential of Treg-derived extracellular vesicles (Treg-EVs) in diseases and theranostics, facilitating further research and application of Treg-EVs.
Women’s Health in Calgary Gets Multi-Year Boost Thanks to $10M Investment through Calgary Health Foundation
[Calgary Health Foundation (Globe Newswire)] Calgary Health Foundation announces a $10M investment over two years from the Government of Alberta in support of women’s health initiatives. This commitment will impact healthcare for women throughout southern Alberta. The one-time investment represents a tangible first step toward removing gender disparity in healthcare practice, policy, research, and care.
Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance
[Clinical Cancer Research] Transcriptomics and high dimensional flow cytometry revealed changes in murine tumor dendritic cells that not only mediated Treg infiltration after radiotherapy, but were associated with worse survival in human cancer datasets.
Biomimetic Nanodrug Blocks CD73 to Inhibit Adenosine and Boosts Antitumor Immune Response Synergically With Photothermal Stimulation
[Journal Of Nanobiotechnology] The release of α, β-Methyleneadenosine 5′-diphosphate suppressed the adenosine generation via CD73 blockade, alleviating the impairment of adenosine to dendritic cells and suppressing regulatory T cells, and synergically stimulated the activity of T cells.
ScRNA-Seq Reveals Novel Immune-Suppressive T Cells and Investigates CMV-TCR-T Cells Cytotoxicity Against GBM
[Journal For Immunotherapy Of Cancer] Investigators highlighted the interaction between bipositive TAMs or cancer cells and T cells was predominantly focused on FXYD6+ T cells rather than regulatory T cells, whereas, FXYD6+ T cells were further identified as a group of novel immunosuppressive T cells.
T Cell Characteristics Impact Response and Resistance to T Cell-Redirecting Bispecific Antibodies in Multiple Myeloma
[Clinical Cancer Research] The anti-multiple myeloma (MM) activity of teclistamab and talquetamab was evaluated in bone marrow (BM) samples from MM patients. T cell phenotype and function were assessed in BM/peripheral blood samples obtained from MM patients who were treated with these bispecific antibodies.
YTHDF1 Regulates Immune Cell Infiltration in Gastric Cancer via Interaction With p53
[Experimental And Therapeutic Medicine] Researchers evaluated the roles of YTH N6‑methyladenosine RNA binding protein 1 (YTHDF1) and p53 in regulating the tumor microenvironment in gastric cancer. Genetic alterations in the YTH domain family were analyzed using the cBioPortal database.
TYM-3-98, a Novel Selective Inhibitor of PI3Kδ, Demonstrates Promising Preclinical Antitumor Activity in B-Cell Lymphomas
[Life Sciences] In vivo, TYM-3-98 showed good pharmaceutical properties and remarkably reduced tumor growth in a human lymphoma xenograft model and a mouse lymphoma model.
Up-Regulated PLA2G10 in Cancer Impairs T Cell Infiltration to Dampen Immunity
[Science Immunology] Scientists identified a role for phospholipase A2 group 10 (PLA2G10) protein in T cell exclusion. They implicated a role for PLA2G10 in T cell exclusion from tumors and suggests a potential target for cancer immunotherapy.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
