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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Pretreatment with IL-15 and IL-18 Rescues Natural Killer Cells From Granzyme B-Mediated Apoptosis after Cryopreservation
[Nature Communications] Using CRISPR-Cas9 gene editing and confocal microscopy, investigators found that cryopreserved Natural Killer cells largely died via apoptosis initiated by leakage of granzyme B from cytotoxic vesicles.
Fate Therapeutics Announces First Lupus Patient Treated in Phase 1 Autoimmunity Study of Off-the-shelf FT819 CAR T-cell Program
[Fate Therapeutics, Inc.] Fate Therapeutics, Inc. announced that the first patient with systemic lupus erythematosus has been treated in the Phase I autoimmunity study of FT819, the company’s off-the-shelf, CD19-targeted chimeric antigen receptor T cell program.
Atypical Chemokine Receptors in the Immune System
[Nature Reviews Immunology] The authors described the contribution of the various atypical chemokine receptors to innate and adaptive immune responses, focussing specifically on recent progress.
The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance
[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, researchers identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.
Traverse Biotech Awarded Phase I SBIR Grant by the National Institute of Allergy and Infectious Diseases for Development of Innate Immune Stimulator
[Traverse Biotech, Inc. (PR Newswire)] Traverse Biotech, Inc. has been awarded a Phase I Small Business Innovation Research grant from the National Institute of Allergy and Infectious Diseases, part of the NIH.
BTK Drives Neutrophil Activation for Sterilizing Antifungal Immunity
[Journal Of Clinical Investigation] Upon fungal exposure, BTK was activated in human neutrophils in a TLR2-, Dectin-1-, and FcγR-dependent manner, triggering the oxidative burst.
Intravital Imaging of the Human Cornea Reveals the Differential Effects of Season on Innate and Adaptive Immune Cell Morphodynamics
[Ophthalmology] Researchers investigated the effect of seasonal-driven environmental factors on the density, morphology, and dynamic behavior of human corneal immune cell subsets.
Pan-Cancer Analysis of Prognostic and Immunological Role of IL4I1 in Human Tumors: A Bulk Omics Research and Single Cell Sequencing Validation
[Discover Oncology] IL4I1 was significantly overexpressed in the majority of tumors, and the imbalance of IL4I1 was significantly correlated with overall survival and pathological stage. Moreover, total IL4I1 protein was increased in cancer.
T Cell Expression of CXCL13 Is Associated with Immunotherapy Response in a Sex-Dependent Manner in Patients with Lung Cancer
[Cancer Immunology Research] The authors investigated differences in T cell responses between male and female patients with lung cancer by performing sex-based analysis of single cell transcriptomic datasets.
PGRN Is Involved in Macrophage M2 Polarization Regulation through TNFR2 in Periodontitis
[Journal Of Translational Medicine] Immunohistochemical and multiplex immunohistochemical stainings were performed to evaluate the expression of macrophage-related markers and progranulin (PGRN) in gingival samples from periodontally healthy subjects and periodontitis subjects.
Israeli Researchers Measure Interaction Between Immune Cells and Cancer Cells
[The Jerusalem Post] A new technology developed at Bar-Ilan University in Ramat Gan and funded by the Israel Cancer Association will help oncologists and other medical professionals to determine the best way to help patients.
Immunotherapy Drives Mesenchymal Tumor Cell State Shift and TME Immune Response in Glioblastoma Patients
[Neuro-Oncology] Investigators present the integrative paired single-cell RNA-seq analysis of 76 tumor samples from patients in a clinical trial of the PD-1 inhibitor nivolumab and untreated patients.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
