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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Multimodal Decoding of Human Liver Regeneration
[Nature] The authors uncovered a novel ANXA2+ migratory hepatocyte subpopulation, which emerged during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen-induced liver regeneration.
TLR3 Activation Enhances Abscopal Effect of Radiotherapy in HCC by Promoting Tumor Ferroptosis
[EMBO Molecular Medicine] Scientists demonstrated that subcutaneous administration of Toll-like receptor 3 (TLR3) agonist poly(I:C) could strengthen the abscopal effect during radiotherapy through activating tumor cell ferroptosis signals in bilateral HCC subcutaneous tumor mouse models, which could be significantly abolished by TLR3 knock-out or ferroptosis inhibitor ferrostatin-1.
Expression of Fascin-1 and Its Diagnostic Value in Liver Cancer
[Scientific Reports] Researchers analyzed the expression level of FSCN1 protein in liver cancer tissues and explored its diagnostic and application value in differentiating between HCC and intrahepatic cholangiocarcinom
Kupffer Cell Diversity Maintains Liver Function in Alcohol-Associated Liver Disease
[Hepatology] Scientists used a Western Diet Alcohol mouse model of alcohol-associated liver disease (ALD) to examine the hepatic myeloid cell compartment by scRNA seq and targeted Kupffer cell ablation to understand the diversity and function of liver macrophages in ALD.
Roles and Therapeutic Targeting of Dendritic Cells in Liver Fibrosis
[Journal Of Drug Targeting] The authors describe the process of fibrogenesis, and the phenotypic and functional characteristics of dendritic cells in the liver.
Multimodal Decoding of Human Liver Regeneration
[Nature] The authors uncovered a novel ANXA2+ migratory hepatocyte subpopulation, which emerged during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen-induced liver regeneration.
TLR3 Activation Enhances Abscopal Effect of Radiotherapy in HCC by Promoting Tumor Ferroptosis
[EMBO Molecular Medicine] Scientists demonstrated that subcutaneous administration of Toll-like receptor 3 (TLR3) agonist poly(I:C) could strengthen the abscopal effect during radiotherapy through activating tumor cell ferroptosis signals in bilateral HCC subcutaneous tumor mouse models, which could be significantly abolished by TLR3 knock-out or ferroptosis inhibitor ferrostatin-1.
Autonomous Circadian Rhythms in the Human Hepatocyte Regulate Hepatic Drug Metabolism and Inflammatory Responses
[MIT News] Investigators established and characterized an in vitro liver experimental system in which primary human hepatocytes display self-sustained oscillations.
METTL14 Downregulation Drives S100A4+ Monocyte-Derived Macrophages via MyD88/NF-κB Pathway to Promote MAFLD Progression
[Signal Transduction And Targeted Therapy] In vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner, which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1+Ccr2+ monocyte-derived macrophages.
Theaflavin-3,3′-Digallate Protects Liver and Kidney Functions in Diabetic Rats by Up-Regulating Circ-ITCH and Nrf2 Signaling Pathway
[Journal Of Agricultural And Food Chemistry] Research indicated that TFDG administration effectively lowered the fasting blood glucose and serum lipid concentrations and enhanced the functionality and cellular architecture of the liver and kidney in rats with diabetes.
Native and Engineered Extracellular Vesicles: Novel Tools for Treating Liver Disease
[Journal Of Materials Chemistry B] The authors introduce the mechanisms and effects of native extracellular vesicles derived from different cells and tissues to treat liver diseases of different etiologies.
Integration of Single-Cell RNA-Seq and Bulk RNA-Seq to Construct Liver Hepatocellular Carcinoma Stem Cell Signatures to Explore Their Impact on Patient Prognosis and Treatment
[PLOS One] The authors explored the association of stemness indicators with survival outcomes and clinical characteristics by combining clinical information and survival analyses.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
