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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Phase III Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis
[New England Journal of Medicine] In this ongoing phase III, multicenter, randomized, double-blind, placebo-controlled trial, investigators assigned 1197 patients with biopsy-defined metabolic dysfunction–associated steatohepatitis and fibrosis stage 2 or 3 in a 2:1 ratio to receive once-weekly subcutaneous semaglutide at a dose of 2.4 mg or placebo for 240 weeks.
A Symbiotic Filamentous Gut Fungus Ameliorates MASH via a Secondary Metabolite-CerS6-Ceramide Axis
[Science] The authors investigated whether gut fungi play a role in host disease and particularly in metabolic dysfunction–associated steatohepatitis (MASH) progression in mouse models.
Bayer Initiates Phase I Study Targeting GPC3 with Actinium-225 Radiopharmaceutical in Patients with Advanced Hepatocellular Carcinoma
[Bayer] Bayer announced the initiation of a Phase I clinical trial with 225Ac-GPC3, an investigational targeted alpha radiopharmaceutical being developed to treat tumors expressing glypican-3 (GPC3) in patients with advanced HCC.
FBL Promotes Hepatocellular Carcinoma Tumorigenesis and Progression by Recruiting YY1 to Enhance CAD Gene Expression
[Cell Death & Disease] The authors investigated key epigenetic regulators that contribute to tumorigenesis and progression, providing a theoretical basis for targeted therapy for HCC.
Intra-Hepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations
[Cancer Discovery] Researchers performed multi-omics profiling of 242 HCC tumor nodules and 58 adjacent non-tumor tissues from 58 multifocal HCC patients, revealing heterogeneous microbial communities in multifocal HCC.
Systemic Treatment in Patients with Hepatocellular Carcinoma and Advanced Liver Dysfunction
[Gut] Scientists discuss how the clinical course of cirrhosis can affect eligibility to treatment in the modern era of systemic therapy for HCC.
POU6F2 Promotes Liver Metastasis of Gastric Adenocarcinoma by Dual Mechanism of Transcriptional Upregulation of SNAI1 and IGF2/PI3K/AKT Signaling-Induced Conversion of Hepatic Stellate Cells into...
[British Journal of Cancer] POU6F2 expression was examined by real-time PCR, Western blot, and immunohistochemical staining.
Solute Carrier Family 2 Member 2 (Glucose Transporter 2): A Common Factor of Hepatocyte and Hepatocellular Carcinoma Differentiation
[PLOS One] Scientists investigated SLC2A2’s role in liver differentiation using in silico, in vitro, and in vivo approaches.
m6a-Modified MIR670HG Suppresses Tumor Liver Metastasis through Enhancing Kupffer Cell Phagocytosis
[Cellular and Molecular Life Sciences] Researchers demonstrated that the MIR670 host gene (MIR670HG) significantly suppressed tumor liver metastasis by enhancing phagocytosis of various tumor cells by Kupffer cells.
Ketogenesis Mitigates Metabolic Dysfunction-Associated Steatotic Liver Disease through Mechanisms That Extend beyond Fat Oxidation
[Journal of Clinical Investigation] Researchers performed stable-isotope tracing and formal flux modeling to quantify hepatic oxidative fluxes in humans across the spectrum of metabolic dysfunction-associated steatotic liver disease-metabolic dysfunction-associated steatohepatitis, and in mouse models of impaired ketogenesis.
Copper-Mediated SEC14L3 Promotes Cuproptosis to Inhibit Hepatocellular Carcinoma Growth via ERK/YY1/FDX1 Axis
[Communications Biology] Researchers revealed that SEC14L3 expression was downregulated in HCC cells and tissues and correlated with advanced stages and poor prognosis.
B Cell-Derived Acetylcholine Promotes Liver Regeneration by Regulating Kupffer Cell and Hepatic CD8+ T Cell Function
[Immunity] Scientists demonstrated that B cells expressing choline acetyltransferase, which synthesizes acetylcholine, were required for liver regeneration.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
