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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
[Cancer Immunology Research] Researchers designed MP0533, a multispecific CD3-engaging designed ankyrin repeat protein that could simultaneously bind to three antigens on AML cells, CD33, CD123, and CD70, aiming to enable avidity-driven T cell–mediated killing of AML cells co-expressing at least two of the antigens.
GPATCH8 Modulates Mutant SF3B1 Mis-Splicing and Pathogenicity in Hematologic Malignancies
[Molecular Cell] The authors utilized synthetic introns uniquely responsive to mutant SF3B1 to identify trans factors required for aberrant mutant SF3B1 splicing activity.
Subsequent Malignant Neoplasms after Primary Hematological Malignancy in Adult Patients
[International Journal of Cancer] The authors identified 45,533 patients aged ≥20 years and diagnosed with primary hematological malignancy in Finland from 1992 to 2019 from the Finnish Cancer Registry and estimated standardized incidence ratios and excess absolute risks per 1000 person-years for subsequent malignant neoplasms.
Clonal Hematopoiesis–Derived Therapy-Related Myeloid Neoplasms after Autologous Hematopoietic Stem Cell Transplant for Lymphoid and Non-Lymphoid Disorders
[Leukemia] Scientists studied a cohort of 1507 patients undergoing autologous hematopoietic stem cell transplantation (aHSCT) and a cohort of 263 patients who developed therapy-related myeloid neoplasms (tMN) without aHSCT to determine clinico-molecular features unique to post-aHSCT tMN.
Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia
[New England Journal Of Medicine] The authors conducted an open-label, single-group, Phase III study of exa-cel in patients 12 to 35 years of age with transfusion-dependent β-thalassemia and a β0/β0, β0/β0-like, or non–β0/β0-like genotype.
Putting the STING Back into BH3-Mimetic Drugs for TP53-Mutant Blood Cancers
[Cancer Cell] Investigators reported that p53 was activated following BH3-mimetic induced mitochondrial outer membrane permeabilization, leading to BH3-only protein induction and thereby potentiating the pro-apoptotic signal.
Pyrimidine Depletion Enhances Targeted and Immune Therapy Combinations in Acute Myeloid Leukemia
[JCI Insight] Researchers introduced HOSU-53, a dihydroorotate dehydrogenase inhibitor with significant monotherapy activity, which was further enhanced when combined with other standard-of-care therapeutics.
Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity
[Nature Communications] The authors showed that the hyperactivation of Janus kinase 2 by the V617F mutation phosphorylated tyrosine residues in coactivator-associated arginine methyltransferase 1 (CARM1), an important target in hematologic malignancies, increasing its methyltransferase activity and altering its target specificity.
Clinical Associations with a Polygenic Predisposition to Benign Lower White Blood Cell Counts
[Nature Communications] Researchers investigated the clinical consequences of a genetic predisposition toward lower white blood cell (WBC) counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count comprising single nucleotide polymorphisms not associated with disease.
SUCLG1 Restricts POLRMT Succinylation to Enhance Mitochondrial Biogenesis and Leukemia Progression
[EMBO Journal] Investigators reported that expression of tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlated with electron transport chain genes across various TCGA cancer transcriptomes.
PML::RARA and GATA2 Proteins Interact via DNA Templates to Induce Aberrant Self-Renewal in Mouse and Human Hematopoietic Cells
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers defined the genomic binding sites of PML::RARA in primary mouse and human hematopoietic progenitor cells with V5-tagged PML::RARA, using anti-V5-PML::RARA chromatin immunoprecipitation sequencing and CUT&RUN approaches.
Recipient Clonal Hematopoiesis in Allogeneic Bone Marrow Transplantation for Lymphoid Malignancies
[Blood Advances] In this retrospective study, allogeneic blood and marrow transplantation (alloBMT) recipients age 60 and older with lymphoid malignancies were included. Among 97 consecutive patients who received alloBMT between 2017 and 2022, cloal hematopoiesis was detected in 60.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
