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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Mis-Expression of GATA6 Re-programs Cell Fate during Early Hematopoiesis
[Cell Reports] In Max41 transgenic mice, nearly all B cells diverted into the granulocyte lineage. Investigators showed that these mice had an excess of myeloid progenitors, but their common lymphoid progenitor compartment was ablated, and they had few plasmacytoid dendritic cells.
Not Just for Lymphoid Cells: The Role of the Noncanonical NF-κB Signaling Pathway in Early and Late Myelopoiesis with a Focus on Hypereosinophilic Disorders
[Journal of Leukocyte Biology] The authors discuss the molecular machinery within the noncanonical NF-κB pathway, crosstalk with the canonical NF-κB pathway, murine models of noncanonical signaling, as well as how aberrations in this pathway manifest in leukemic or hyperinflammatory disease with a focus on Hypereosinophilic syndrome.
$2.7 Million Grant to Explore Hypoxia’s Impact on Blood Stem Cells
[Indiana University School of Medicine (EurekAlert)] A new four-year, $2.7 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases will support the project, “Hypoxia's role in regulating stressed hematopoietic stem cells,” led byIndiana University School of Medicine scientists.
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
[Cancer Immunology Research] Researchers designed MP0533, a multispecific CD3-engaging designed ankyrin repeat protein that could simultaneously bind to three antigens on AML cells, CD33, CD123, and CD70, aiming to enable avidity-driven T cell–mediated killing of AML cells co-expressing at least two of the antigens.
GPATCH8 Modulates Mutant SF3B1 Mis-Splicing and Pathogenicity in Hematologic Malignancies
[Molecular Cell] The authors utilized synthetic introns uniquely responsive to mutant SF3B1 to identify trans factors required for aberrant mutant SF3B1 splicing activity.
Subsequent Malignant Neoplasms after Primary Hematological Malignancy in Adult Patients
[International Journal of Cancer] The authors identified 45,533 patients aged ≥20 years and diagnosed with primary hematological malignancy in Finland from 1992 to 2019 from the Finnish Cancer Registry and estimated standardized incidence ratios and excess absolute risks per 1000 person-years for subsequent malignant neoplasms.
Clonal Hematopoiesis–Derived Therapy-Related Myeloid Neoplasms after Autologous Hematopoietic Stem Cell Transplant for Lymphoid and Non-Lymphoid Disorders
[Leukemia] Scientists studied a cohort of 1507 patients undergoing autologous hematopoietic stem cell transplantation (aHSCT) and a cohort of 263 patients who developed therapy-related myeloid neoplasms (tMN) without aHSCT to determine clinico-molecular features unique to post-aHSCT tMN.
Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia
[New England Journal Of Medicine] The authors conducted an open-label, single-group, Phase III study of exa-cel in patients 12 to 35 years of age with transfusion-dependent β-thalassemia and a β0/β0, β0/β0-like, or non–β0/β0-like genotype.
Putting the STING Back into BH3-Mimetic Drugs for TP53-Mutant Blood Cancers
[Cancer Cell] Investigators reported that p53 was activated following BH3-mimetic induced mitochondrial outer membrane permeabilization, leading to BH3-only protein induction and thereby potentiating the pro-apoptotic signal.
Pyrimidine Depletion Enhances Targeted and Immune Therapy Combinations in Acute Myeloid Leukemia
[JCI Insight] Researchers introduced HOSU-53, a dihydroorotate dehydrogenase inhibitor with significant monotherapy activity, which was further enhanced when combined with other standard-of-care therapeutics.
Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity
[Nature Communications] The authors showed that the hyperactivation of Janus kinase 2 by the V617F mutation phosphorylated tyrosine residues in coactivator-associated arginine methyltransferase 1 (CARM1), an important target in hematologic malignancies, increasing its methyltransferase activity and altering its target specificity.
Clinical Associations with a Polygenic Predisposition to Benign Lower White Blood Cell Counts
[Nature Communications] Researchers investigated the clinical consequences of a genetic predisposition toward lower white blood cell (WBC) counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count comprising single nucleotide polymorphisms not associated with disease.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
