Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Extracellular Matrix News
Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
RNA Aggregates Harness the Danger Response for Potent Cancer Immunotherapy
[Cell] Researchers created “onion-like” multi-lamellar RNA lipid particle aggregates to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens.
Histological and Immunohistochemical Analyses of Articular Cartilage During Onset and Progression of Pre- and Early-Stage Osteoarthritis in a Rodent Model
[Scientific Reports] On postoperative day three, histological changes, including chondrocyte death, reduced matrix staining, and superficial fibrillation, were observed. Simultaneously, a compensatory increase in matrix staining was observed.
Fibroblast Expression of Transmembrane Protein Smoothened Governs Microenvironment Characteristics After Acute Kidney Injury
[Journal Of Clinical Investigation] Researchers reported that Smo-specific ablation in fibroblasts reduced tubular cell apoptosis and inflammation, enhanced perivascular mesenchymal cells activities, and preserved kidney function after acute kidney injury.
Brain Delivery of Protein Therapeutics by Cell Matrix-inspired Biomimetic Nanocarrier
[Advanced Materials] Inspired by the natural environment of active proteins, scientists used the cell matrix components hyaluronic acid and protamine to self-assemble with proteins to form a protein-loaded biomimetic core and then incorporated it into ApoE3-reconstituted high-density lipoprotein to form a protein-loaded biomimetic nanocarrier.
In Vitro Development of a Muscle-Tendon Junction Construct Using Decellularised Extracellular Matrix: Effect of Cyclic Tensile Loading
[Biomaterials Advances] Decellularized extracellular matrix-derived from sheep muscle tendon junction (MTJ) was used to provide a scaffold for the MTJ with the relevant mechanical properties and differentiation cues such as the relase of growth factors.
NIH Awards Hesperos Research Grant to Develop Animal-Free Botox Testing Platform
[Hesperos, Inc.] Hesperos was awarded a $2 million research grant by the National Center for Advancing Translational Sciences in collaboration with the US FDA. The goal of the effort is to develop an advanced testing platform capable of assessing the potency of the Botulinum Toxin without the need for animal testing.
Midkine Promotes Renal Fibrosis by Stabilizing C/EBPβ to Facilitate Endothelial-Mesenchymal Transition
[Communications Biology] Investigators demonstrated Midkine mainly expressed by CD31 + ACTA2+ECs going through partial EndMT contributed greatly to myofibroblasts by spatial and single-cell transcriptomics.
Mechanical Properties, Collagen and Glycosaminoglycan Content of Equine Superficial Digital Flexor Tendons Are Not Affected by Training
[Journal Of Anatomy] Scientists investigated whether different training histories of horses would influence the synthesis of collagen and other matrix proteins and alter the mechanical properties of tendon.
Synergistic Effects of Matrix Biophysical Properties on Gastric Cancer Cell Behavior via Integrin-Mediated Cell-ECM Interactions
[Small] By combining collagen I and alginate, researchers designed an in vitro biomimetic hydrogel platform to independently modulate matrix stiffness and structure across a physiological stiffness spectrum while preserving consistent collagen concentration and fiber topography.
RNA-Sequencing Suggests Extracellular Matrix and Vasculature Dysregulation Could Impair Neurogenesis in Schizophrenia Cases with Elevated Inflammation
[Schizophrenia] Scientists aimed to discover transcriptomic differences between inflammatory subgroups of schizophrenia in the subependymal zone (SEZ). Total RNA sequencing was performed on SEZ tissue from schizophrenia cases, designated into low inflammation and high inflammation subgroups, based on cluster analysis of inflammation marker gene expression.
The Local Mechanosensitive Response of Primary Cardiac Fibroblasts Is Influenced by the Microenvironment Mechanics
[Scientific Reports] Researchers adopted a multimodal approach, combining the local mechanical stimulation with variations of culture substrate stiffness. They found that primary rat cardiac fibroblasts cultured on stiff substrates showed a broad Piezo1 distribution in the cell with particular accumulation at the mitochondria membrane.
Computational Fluid Dynamics (CFD) Analysis of Bioprinting
[Advanced Healthcare Materials] The authors discuss the current application of computational fluid dynamics in bioprinting and its potential to enhance the technology that can contribute to the evolution of regenerative medicine.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
