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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Focal Clusters of Peri-Synaptic Matrix Contribute to Activity-Dependent Plasticity and Memory in Mice
[Cell Reports] Scientists showed that clusters of the peri-synaptic ECM, recognized by CS56 antibody, emerged in response to sensory stimuli, showing temporal and spatial coincidence with dendritic spine plasticity.
Luxa Biotechnology Receives $4 Million Grant for Clinical Trial of Dry AMD Treatment
[Luxa Biotechnology] Luxa Biotechnology has been awarded a $4 million grant from the California Institute for Regeneration Medicine, supporting its ongoing Phase I/IIa clinical study of the RPESC-RPE-4W cell transplantation for the treatment of dry age-related macular degeneration (AMD).
A Multifunctional Herb-Derived Glycopeptide Hydrogel for Chronic Wound Healing
[Small] Investigators introduced a stimulus-responsive glycopeptide hydrogel constructed by oxidized Bletilla striata polysaccharide, gallic acid-grafted ε-Polylysine, and paeoniflorin-loaded micelles, called OBPG&MP.
Modulating Extracellular Matrix Stiffness: A Strategic Approach to Boost Cancer Immunotherapy
[Cell Death & Disease] The authors addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies.
Development of a Novel High-Throughput Culture System for Hypoxic 3D Hydrogel Cell Culture
[Scientific Reports] As a proof-of-concept, investigators established a 3D culture of gelatin-methacryloyl-encapsulated mesenchymal stem/stromal cells.
Mechanical Stimulation of Induced Pluripotent Stem Derived Cardiac Fibroblasts
[Scientific Reports] The authors confirmed that iPSC-cardiofibroblasts (CFs) were comparable to primary CFs at gene, protein and functional level. Furthermore, iPSC-derived CFs adopted a pro-fibrotic response to transforming growth factor beta.
A Vascularized Breast Cancer Spheroid Platform for the Ranked Evaluation of Tumor Microenvironment-Targeted Drugs by Light Sheet Fluorescence Microscopy
[Nature Communications] Scientists developed a comprehensive screening platform that allows monitoring, quantifying, and ranking drug-induced effects in self-organizing, vascularized tumor spheroids.
Engineering Complex Tissue-Like Microenvironments with Biomaterials and Biofabrication
[Trends In Biotechnology] The authors explore some of the key structural and compositional aspects of tissues, lay out how to achieve similar outcomes with current fabrication strategies, and identify the main challenges and promising avenues for future research.
Designing Biomimetic 3D-Printed Osteochondral Scaffolds for Enhanced Load-Bearing Capacity
[Tissue Engineering Part A] Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer.
TANGO1 Inhibitors Reduce Collagen Secretion and Limit Tissue Scarring
[Nature Communications] Investigators designed membrane permeant peptide inhibitors that specifically target the primary interface between TANGO1 and cTAGE5, an interaction that is required for collagen export from endoplasmic reticulum exit sites
U of T, Hospitals Launch Pilot Program to Boost Commercialization of Medical Innovations
[University of Toronto] The University of Toronto (U of T) is collaborating with the University Health Network, the Hospital for Sick Children, and Sunnybrook Research Institute on a new program that aims to leverage the expertise of entrepreneurs and business leaders to advance commercialization of emerging medical technologies and regenerative medicine research.
Characterization of TGFβ1-Induced Tendon-Like Structure in the Scaffold-Free Three-Dimensional Tendon Cell Culture System
[Scientific Reports] Researchers developed a scaffold-free, 3D tendon culture system using mouse tendon cells in a differentially adherent growth channel.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
