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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
RNA-Sequencing Suggests Extracellular Matrix and Vasculature Dysregulation Could Impair Neurogenesis in Schizophrenia Cases with Elevated Inflammation
[Schizophrenia] Scientists aimed to discover transcriptomic differences between inflammatory subgroups of schizophrenia in the subependymal zone (SEZ). Total RNA sequencing was performed on SEZ tissue from schizophrenia cases, designated into low inflammation and high inflammation subgroups, based on cluster analysis of inflammation marker gene expression.
The Local Mechanosensitive Response of Primary Cardiac Fibroblasts Is Influenced by the Microenvironment Mechanics
[Scientific Reports] Researchers adopted a multimodal approach, combining the local mechanical stimulation with variations of culture substrate stiffness. They found that primary rat cardiac fibroblasts cultured on stiff substrates showed a broad Piezo1 distribution in the cell with particular accumulation at the mitochondria membrane.
Computational Fluid Dynamics (CFD) Analysis of Bioprinting
[Advanced Healthcare Materials] The authors discuss the current application of computational fluid dynamics in bioprinting and its potential to enhance the technology that can contribute to the evolution of regenerative medicine.
Focal Clusters of Peri-Synaptic Matrix Contribute to Activity-Dependent Plasticity and Memory in Mice
[Cell Reports] Scientists showed that clusters of the peri-synaptic ECM, recognized by CS56 antibody, emerged in response to sensory stimuli, showing temporal and spatial coincidence with dendritic spine plasticity.
Luxa Biotechnology Receives $4 Million Grant for Clinical Trial of Dry AMD Treatment
[Luxa Biotechnology] Luxa Biotechnology has been awarded a $4 million grant from the California Institute for Regeneration Medicine, supporting its ongoing Phase I/IIa clinical study of the RPESC-RPE-4W cell transplantation for the treatment of dry age-related macular degeneration (AMD).
A Multifunctional Herb-Derived Glycopeptide Hydrogel for Chronic Wound Healing
[Small] Investigators introduced a stimulus-responsive glycopeptide hydrogel constructed by oxidized Bletilla striata polysaccharide, gallic acid-grafted ε-Polylysine, and paeoniflorin-loaded micelles, called OBPG&MP.
Modulating Extracellular Matrix Stiffness: A Strategic Approach to Boost Cancer Immunotherapy
[Cell Death & Disease] The authors addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies.
Development of a Novel High-Throughput Culture System for Hypoxic 3D Hydrogel Cell Culture
[Scientific Reports] As a proof-of-concept, investigators established a 3D culture of gelatin-methacryloyl-encapsulated mesenchymal stem/stromal cells.
Mechanical Stimulation of Induced Pluripotent Stem Derived Cardiac Fibroblasts
[Scientific Reports] The authors confirmed that iPSC-cardiofibroblasts (CFs) were comparable to primary CFs at gene, protein and functional level. Furthermore, iPSC-derived CFs adopted a pro-fibrotic response to transforming growth factor beta.
A Vascularized Breast Cancer Spheroid Platform for the Ranked Evaluation of Tumor Microenvironment-Targeted Drugs by Light Sheet Fluorescence Microscopy
[Nature Communications] Scientists developed a comprehensive screening platform that allows monitoring, quantifying, and ranking drug-induced effects in self-organizing, vascularized tumor spheroids.
Engineering Complex Tissue-Like Microenvironments with Biomaterials and Biofabrication
[Trends In Biotechnology] The authors explore some of the key structural and compositional aspects of tissues, lay out how to achieve similar outcomes with current fabrication strategies, and identify the main challenges and promising avenues for future research.
Designing Biomimetic 3D-Printed Osteochondral Scaffolds for Enhanced Load-Bearing Capacity
[Tissue Engineering Part A] Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
