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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Synergistic Antitumor Activity by Dual Blockade of CCR1 and CXCR2 Expressed on Myeloid Cells within the Tumor Microenvironment
[British Journal Of Cancer] Investigators generated double-knockout mice for CCR1 and CXCR2, and performed bone marrow transfer experiments in which sub-lethally irradiated wild-type mice were reconstituted with bone marrow from either wild-type, Ccr1−/−, Cxcr2−/− or Ccr1−/−Cxcr2−/− mice.
Confined Bioprinting and Culture in Inflatable Bioreactor for the Sterile Bioproduction of Tissues and Organs
[Scientific Reports] The authors introduced a novel device called the Flexible Unique Generator Unit, which is a unique combination of flexible silicone membranes and solid components made of stainless steel.
Navigating the Tumor Microenvironment: Mesenchymal Stem Cell-Mediated Delivery of Anticancer Agents
[Journal Of Drug Targeting] The authors elaborates on recent advancements of mesenchyma stem cell mediated drug delivery of anti-cancer agents along with its mechanism and previously reported studies of drugs manufactured via this drug delivery system.
Engineering Cell Instructive Microenvironments for In Vitro Replication of Functional Barrier Organs
[Advanced Healthcare Materials] The authors explored current limitations to in vitro organ morphogenesis, emphasizing the interplay of gene regulatory networks, mechanical factors, and tissue microenvironment cues.
RNA Aggregates Harness the Danger Response for Potent Cancer Immunotherapy
[Cell] Researchers created “onion-like” multi-lamellar RNA lipid particle aggregates to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens.
Histological and Immunohistochemical Analyses of Articular Cartilage During Onset and Progression of Pre- and Early-Stage Osteoarthritis in a Rodent Model
[Scientific Reports] On postoperative day three, histological changes, including chondrocyte death, reduced matrix staining, and superficial fibrillation, were observed. Simultaneously, a compensatory increase in matrix staining was observed.
Fibroblast Expression of Transmembrane Protein Smoothened Governs Microenvironment Characteristics After Acute Kidney Injury
[Journal Of Clinical Investigation] Researchers reported that Smo-specific ablation in fibroblasts reduced tubular cell apoptosis and inflammation, enhanced perivascular mesenchymal cells activities, and preserved kidney function after acute kidney injury.
Brain Delivery of Protein Therapeutics by Cell Matrix-inspired Biomimetic Nanocarrier
[Advanced Materials] Inspired by the natural environment of active proteins, scientists used the cell matrix components hyaluronic acid and protamine to self-assemble with proteins to form a protein-loaded biomimetic core and then incorporated it into ApoE3-reconstituted high-density lipoprotein to form a protein-loaded biomimetic nanocarrier.
In Vitro Development of a Muscle-Tendon Junction Construct Using Decellularised Extracellular Matrix: Effect of Cyclic Tensile Loading
[Biomaterials Advances] Decellularized extracellular matrix-derived from sheep muscle tendon junction (MTJ) was used to provide a scaffold for the MTJ with the relevant mechanical properties and differentiation cues such as the relase of growth factors.
NIH Awards Hesperos Research Grant to Develop Animal-Free Botox Testing Platform
[Hesperos, Inc.] Hesperos was awarded a $2 million research grant by the National Center for Advancing Translational Sciences in collaboration with the US FDA. The goal of the effort is to develop an advanced testing platform capable of assessing the potency of the Botulinum Toxin without the need for animal testing.
Midkine Promotes Renal Fibrosis by Stabilizing C/EBPβ to Facilitate Endothelial-Mesenchymal Transition
[Communications Biology] Investigators demonstrated Midkine mainly expressed by CD31 + ACTA2+ECs going through partial EndMT contributed greatly to myofibroblasts by spatial and single-cell transcriptomics.
Mechanical Properties, Collagen and Glycosaminoglycan Content of Equine Superficial Digital Flexor Tendons Are Not Affected by Training
[Journal Of Anatomy] Scientists investigated whether different training histories of horses would influence the synthesis of collagen and other matrix proteins and alter the mechanical properties of tendon.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
