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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Betaglycan Sustains HGF/Met Signaling in Lung Cancer and Endothelial Cells Promoting Cell Migration and Tumor Growth
[Heliyon] Scientists found that HGF/Met promoted lung cancer and endothelial cells migration via PI3K and mTOR. This effect was enhanced by recombinant soluble betaglycan via a mechanism attributable to its glycosaminoglycan chains, as a mutant without them did not modulate HGF effects.
Hypoxia Modulates P-Glycoprotein (P-GP) and Breast Cancer Resistance Protein (BCRP) Drug Transporters in Brain Endothelial Cells of the Developing Human Blood-Brain Barrier
[Heliyon] The authors investigated how hypoxia impacts multidrug resistance transporters in human fetal brain endothelial cells derived from early and mid-stages of pregnancy.
Metabolic Reprogramming and Interventions in Angiogenesis
[Journal Of Advanced Research] The authors discuss the metabolic regulation of angiogenesis by endothelial cell (EC) metabolites and metabolic enzymes, as well as prospect the possible therapeutic opportunities and strategies targeting EC metabolism.
Tissue-Engineered Microvessels: A Review of Current Engineering Strategies and Applications
[Advanced Healthcare Materials] Scientists summarize recent progress in engineering approaches, key components, and culture platforms for tissue-engineered human microvessel models.
MCG Scientists Identify New Treatment Target for Leading Cause of Blindness
[Medical College of Georgia (EurekAlert!)] Medical College of Georgia scientists report that a gene previously implicated in the development of atherosclerotic lesions in coronary arteries could be key to understanding why many people don’t benefit from the most used therapy for neovascular age-related macular degeneration, a leading cause of blindness.
NADPH Oxidase 4-Derived Hydrogen Peroxide Counterbalances Testosterone-Induced Endothelial Dysfunction and Migration
[American Journal of Physiology - Endocrinology and Metabolism] Human mesenteric vascular endothelial cells and human umbilical vein endothelial cells were treated with Testo with or without a NOX4 inhibitor or NOX4 siRNA.
HIF-1α-Dependent Upregulation of Angiogenic Factors by Mechanical Stimulation in Retinal Pigment Epithelial Cells
[Disease Models & Mechanisms] Researchers investigated and characterized the effects of mechanical stimulation on the expression of angiogenic factors in retinal pigment epithelial cells both in vitro and in a mouse model.
Viral Entry and Translation in Brain Endothelia Provoke Influenza-Associated Encephalopathy
[Acta Neuropathologica] Researchers showed that influenza virus entered into the cerebral endothelium and thereby induced influenza-associated encephalopathy. Three-weeks-old young mice were inoculated with influenza A virus.
Nanosheet Promotes Chronic Wound Healing by Localizing Uncultured Stromal Vascular Fraction Cells
[Advances In Wound Care] Researchers developed an efficacious and efficient method for treating chronic wounds using “nanosheet” that improved the survival and localization of transplanted cells without prior seeding to optimally derive the regenerative potentials of uncultured stromal vascular fraction cells.
Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy
[Circulation Research] To understand the importance of endothelial proliferation and migration for the beneficial versus adverse effects of vascular endothelial growth factor B (VEGF-B) in the heart, investigators explored the cardiac effects of autocrine versus paracrine VEGF-B expression in transgenic and gene-transduced mice.
A New Type of Blood–Brain Barrier Aminoacidopathy Underlies Metabolic Microcephaly Associated With SLC1A4 Mutations Get Access Arrow
[Brain] Scientists examined the phenotype and metabolic profile of three Slc1a4 mouse models, including a constitutive Slc1a4-KO mouse, a knock-in mouse with the major human Slc1a4 mutation, and a selective knockout of Slc1a4 in brain endothelial cells.
ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels
[Circulation] Investigators analyzed colony-forming, self-renewal, and vessel-forming potential of ATP binding cassette subfamily G member 2 (ABCG2)–expressing endothelial cells in human umbilical vessels. They developed Abcg2CreErt2;ROSA TdTomato mice and performed lineage tracing during mouse development and during tissue regeneration after myocardial infarction injury.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
