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Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Sylvester Cancer Adding Cellular Therapy to its Arsenal against Metastatic Melanoma
[University of Miami Miller School of Medicine (EurekAlert!)] Patients in South Florida with metastatic melanoma will soon have access to tumor-infiltrating lymphocyte therapy, following its recent approval by the FDA. It will be available to patients at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine.
The Role of Yes Activated Protein (YAP) in Melanoma Metastasis
[iScience] The authors discuss how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.
Exploration of the Photothermal Role of Curcumin-Loaded Targeted Carbon Nanotubes as a Potential Therapy for Melanoma Cancer
[Scientific Reports] Scientists designed and evaluated targeted carbon nanotubes containing curcumin, and assessed their in vitro cytotoxicity effects on melanoma cancer cells.
Lysophosphatidic Acid Down-Regulates Human RIPK4 mRNA in Keratinocyte-Derived Cell Lines
[PLOS One] A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.
Dermavant Announces FDA Acceptance of Supplemental New Drug Application (sNDA) for VTAMA® (Tapinarof) Cream, 1% for the Treatment of Atopic Dermatitis in Adults and...
[Dermavant Sciences, Inc.] Dermavant Sciences, Inc. announced that the US FDA accepted the company’s sNDA for VTAMA® cream, 1% for the topical treatment of atopic dermatitis in adults and children two years of age and older.
Skin Graft with Dermis and Appendages Generated In Vivo by Cell Competition
[Nature Communications] Scientists generated complete skin grafts with pluripotent stem cell-derived epidermis with appendages on p63 knockout embryos’ dermis.
Ribosomal S6 Kinase 2-Forkhead Box Protein O4 Signaling Pathway Plays an Essential Role in Melanogenesis
[Scientific Reports] Investigators reported that α-melanocyte-stimulating hormone, not ultraviolet (UV) UVA and UVB, acted as a major stimulus of melanogenesis in melanoma cells.
The Involvement of RIPK4 in TNF-α-Stimulated IL-6 and IL-8 Production by Melanoma Cells
[Journal Of Cancer Research And Clinical Oncology] The authors examined the effects of receptor-interacting protein kinase (RIPK4) downregulation on the transcriptomic profile of melanoma, and revealed a complex role for RIPK4 in regulating the immune signaling network in melanoma cells.
Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing
[Pigment Cell & Melanoma Research] Using a cell enrichment strategy to isolate KIT+/CD45− cells from the telogen skin of adult female C57BL/6J mice, investigators evaluated the transcriptional landscape of quiescent melanocyte stem cells at high resolution.
Lysophosphatidic Acid Down-Regulates Human RIPK4 mRNA in Keratinocyte- Derived Cell Lines
[PLOS One] A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.
Cell Death as an Architect of Adult Skin Stem Cell Niches
[Cell Death & Differentiation] Investigators described how regulated cell death modalities functionally affect epidermal SC niches along with their relevance to injury repair, inflammatory skin disorders and cancer.
Lipid-Based Nanoparticles as a Promising Treatment for the Skin Cancer
[Heliyon] Scientists examine the properties and applications of nanoliposomes used in the treatment and prevention of numerous types of skin cancer.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
