Cord Blood News

[Journal Of Experimental Medicine] γδ T cells were investigated in a longitudinal cohort of preterm neonates using next-generation sequencing, flow cytometry, and functional assays. During the first year of life, the Vγ9Vδ2 T cell subset showed dynamic phenotypic changes and elevated levels of fetal-derived Vγ9Vδ2 T cells were evident in infants with sepsis.

[Journal Of Immunotherapy of Cancer] Investigators developed and validated a pathomics-driven ensemble model for predicting the response to immune checkpoint inhibitors in gastric cancer, using H&E-stained whole slide images.

[Hepatology Research] Scientists reported a case of fulminant hepatitis in a hepatitis B surface antigen-positive patient with aggressive adult T cell leukemia-lymphoma who received monotherapy with an anti-CCR4 monoclonal antibody, mogamulizumab, with decreased hepatitis B virus- DNA levels by entecavir prophylaxis.

[Clinical Immunology] Investigators assessed the ability of DONQ52 to inhibit coeliac disease patient-derived T cell responses to the most immunogenic gluten peptides encompassing immunodominant T cell epitopes.

[Acta Pharmacologica Sinica] Researchers investigated whether and how bevacizumab regulated ferroptosis and immune activity in liver cancer. They performed RNA-sequencing in bevacizumab-treated human liver cancer cell line HepG2 cells, and found that bevacizumab significantly altered the expression of a number of genes including VEGF, PI3K, HAT1, SLC7A11 and IL-9 in liver cancer, bevacizumab upregulated 37 ferroptosis-related drivers.

[Journal Of Investigative Dermatology] Researchers showed that expression of HLA-DR, high-affinity receptors for Staphylococcal enterotoxins, by keratinocytes correlated with IFN-γ expression in the tumor microenvironment. Importantly, IFN-γ induced HLA-DR, SE-binding, and SE-presentation by keratinocytes to malignant T-cells from Sézary syndrome patients.

[Clinical Cancer Research] The authors present how arming Vδ2-T cells might be the basis for next-generation immunotherapies against solid tumors. Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, we will discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.

[Nature Cardiovascular Research] Researchers showed unique dysregulated pathways in splenic compared to bone marrow endothelial cells during atherosclerosis, including perturbations of lipid metabolism and endocytic trafficking pathways.

[Nature Communications] Investigators showed that FOXC1 was essential for retinal angiogenesis. Endothelial cell-specific loss of Foxc1 impaired retinal vascular growth and expression of Slc3a2 and Slc7a5, which encoded the heterodimeric CD98 amino acid transporter and regulated the intracellular transport of essential amino acids and activation of the mammalian target of rapamycin.

[Nature Communications] Scientists reported a Sox17-Erg direct reprogramming approach that used cardiac fibroblasts to create differentiated endothelial cells that demonstrated endothelial-like molecular and physiological functions in vitro and in vivo.

[Hypertension Research] The obesity-related hypertension rats induced by high-fat diet for 28 weeks and the human umbilical vein endothelial cells-treated by palmitic acid were used to investigate the effects of adrenomedullin on endothelial dysfunction and the underlying mechanisms.

[Nature Communications] Researchers demonstrated that a gp120-based vaccine can elicit antibodies capable of tier 2-HIV neutralization. They reported the isolation and characterization of a CD4-binding site specific monoclonal antibody, HmAb64, from a human volunteer immunized with a polyvalent DNA prime-protein boost HIV vaccine.