Cord Blood News

[Blood Cancer Journal] Long-term EBMT registry data were used to provide large scale, up-to-date outcome results and to identify factors for improved outcome

[Neuron] Scientists detailed the safe application of anti-CD19 CAR T cells for treating concomitant MG/LEMS. After CAR T cell therapy, both patients experienced rapid clinical recovery and regained full mobility.

[Bioactive Materials] The authors introduce strategies based on biomaterial-assisted Treg immunotherapy to enhance transplant medicine and autoimmune treatments.

[Acta Biomaterialia] Investigators discuss existing treatment strategies following muscle damage, recent progress in bioprinting techniques, the bioinks used for muscle regeneration, the immunogenicity of scaffold materials, and in vitro and in vivo maturation techniques for 3D bio-printed muscle constructs.

[Heliyon] Scientists found that HGF/Met promoted lung cancer and endothelial cells migration via PI3K and mTOR. This effect was enhanced by recombinant soluble betaglycan via a mechanism attributable to its glycosaminoglycan chains, as a mutant without them did not modulate HGF effects.

[Heliyon] The authors investigated how hypoxia impacts multidrug resistance transporters in human fetal brain endothelial cells derived from early and mid-stages of pregnancy.

[Circulation] Investigators analyzed colony-forming, self-renewal, and vessel-forming potential of ATP binding cassette subfamily G member 2 (ABCG2)–expressing endothelial cells in human umbilical vessels.

[Journal Of Advanced Research] The authors discuss the metabolic regulation of angiogenesis by endothelial cell (EC) metabolites and metabolic enzymes, as well as prospect the possible therapeutic opportunities and strategies targeting EC metabolism.

[Advanced Healthcare Materials] Scientists summarize recent progress in engineering approaches, key components, and culture platforms for tissue-engineered human microvessel models.

[Medical College of Georgia (EurekAlert!)] Medical College of Georgia scientists report that a gene previously implicated in the development of atherosclerotic lesions in coronary arteries could be key to understanding why many people don’t benefit from the most used therapy for neovascular age-related macular degeneration, a leading cause of blindness.

[Neuro-Oncology] Investigators present the integrative paired single-cell RNA-seq analysis of 76 tumor samples from patients in a clinical trial of the PD-1 inhibitor nivolumab and untreated patients.

[Trends In Endocrinology And Metabolism] The authors describe recent findings from clinical trials, observational studies of human patients, and animal studies on the impact of the microbiome on the efficacy of immune checkpoint blockade.