Cord Blood News

[Burns & Trauma] Scientists utilized gradient extrusion to produce fibroblast-derived exosome-mimetic vesicles as carriers for matrine (MHEM), and the therapeutic effect of MHEM in wound healing was explored in vitro and in vivo.

[EMBO Journal] Using single-cell RNA sequencing, researchers produced an atlas of matched mouse mammary epithelium and mesenchyme and reconstructed the differentiation trajectories of multipotent stem cells toward basal and luminal fate.

[Cancer Discovery] Scientists employed functional genomics to dissect the contribution of cis-regulatory elements (CREs) to cancer evolution. Parallel epigenetic perturbation in vitro revealed context-dependent roles for many CREs, with a specific impact on dormancy entrance and endocrine therapy resistance.

[ACS Nano] A variety of biophysical techniques, in vitro assays, and in vivo experiments uncovered the plant-derived anti-human epidermal growth factor receptor 2 (HER2) antibody's nanoscale binding dynamics with transmembrane HER2 on living cells.

[British Journal Of Cancer] Human cell lines and mouse models of disease progression were analyzed for candidate risk predictive biomarkers identified and validated in two independent ductal carcinoma in situcohorts.

[Gut] Researchers used a mouse model and primary tumour cell lines to investigate putative cancer stem cell (CSC) populations. They established peptidoglycan recognition protein 1 (PGLYRP1) as a novel CSC-associated marker crucial for immune evasion.

[Cancer Research] Investigators reported the application of an allysine-targeted molecular magnetic resonance imaging probe, MnL3, to provide an early, noninvasive assessment of treatment response in PDAC. Molecular MRI with MnL3 could specifically detect and quantify fibrogenesis in PDAC xenografts.

[iScience] Scientists investigated the molecular mechanism of obg-like ATPase 1 (OLA1) underlying gemcitabine (GEM)-induced drug resistance. An enhanced expression of OLA1 was observed in a GEM acquired resistant pancreatic cancer cell lines and in patients with pancreatic cancer.

[Cell Death & Disease] Researchers investigated the contribution of Reg4 to the pathogenesis of pancreatitis and evaluated its therapeutic effects in experimental pancreatitis.

[Gastroenterology] Scientists review what is known about the key roles that the integrated stress response (ISR) plays in the development, homeostasis, and neoplasia of the pancreas.

[Cell Death Discovery] The authors focus on the malignant development of hyperlipidemic pancreatitis with severe disease combined with the core features of ferroptosis to explore and describe the mechanism of this phenomenon and show that the activation of lipid peroxidation and the aberrant intracellular release of many inflammatory mediators during ferroptosis are the key processes that regulate the degree of disease development in patients with hyperlipidemic acute pancreatitis.

[Lisata Therapeutics, Inc.] Lisata Therapeutics, Inc. announced that it has reached agreement with the European Medicines Agency on a Pediatric Investigation Plan for Lisata’s lead investigational product, certepetide in pancreatic cancer.