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Cell Therapy News
Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Clonal Relapse Dynamics in Acute Myeloid Leukemia Following Allogeneic Hematopoietic Cell Transplantation
[Blood] Scientists elucidated the molecular architecture and kinetics preceding AML relapse by utilizing error-corrected next-generation sequencing in 74 AML patients relapsing after alloHCT evaluating 140 samples from peripheral blood collected 0.6 to 14 months before relapse.
Outcomes of HLA-Mismatched HSCT With TCRαβ/CD19 Depletion or Post-HSCT Cyclophosphamide for Inborn Errors of Immunity
[Blood] Investigators performed a retrospective multicenter study via the EBMT registry on 306 children with IEI undergoing first transplant between 2010-2019 from an HLA-mismatched donor using TCRαβ or PTCY.
First Fetus-to-Fetus Transplant Demonstrated in Rats
[Nature News] Surgeons in Japan have transplanted kidney tissue from one rat fetus to another, while the recipient was still in its mother's womb. Study lead Takashi Yokoo, a nephrologist at Jikei University School of Medicine in Tokyo, says the surgery is the first step to one day transplanting fetal pig kidneys into human fetuses that develop without functioning kidneys.
CD3 Aptamers Promote Expansion and Persistence of Tumor-Reactive T Cells for Adoptive T Cell Therapy in Cancer
[Molecular Therapy - Nucleic Acids] To identify CD3-specific T cell agonists, several RNA aptamers were selected against CD3 using SELEX combined with high-throughput sequencing.
Selective Refueling of CAR T Cells Using ADA1 and CD26 Boosts Antitumor Immunity
[Cell Reports Medicine] Scientists presented a metabolic refueling approach using inosine as an alternative fuel. CAR T cells were engineered to express membrane-bound CD26 and cytoplasmic adenosine deaminase 1 (ADA1), converting adenosine to inosine.
Controlling CAR T Cell Activity and Specificity with Synthetic SparX Adapters
[Molecular Therapy] Researchers developed a controllable cell therapy where synthetic D-Domain-containing proteins (SparX) bind one or more tumor antigens and mark those cells for elimination by genetically modified T cells
Live-Attenuated Virus Vaccine Defective in RNAi Suppression Induces Rapid Protection in Neonatal and Adult Mice Lacking Mature B and T Cells
[Proceedings Of The National Academy Of Sciences Of The United States Of America] The mosquito-transmitted Nodamura virus was attenuated in mice by mutations that prevent expression of the B2 viral suppressor of RNA interference and consequently, drastically enhance in vivo production of the virus-targeting small-interfering RNAs.
Cell Culture on Suspended Fiber for Tissue Regeneration: A Review
[International Journal Of Biological Macromolecules] The authors compare the effectiveness of 3D suspended fiber scaffolds with 2D culture systems, discussing their respective benefits and limitations in the context of tissue regeneration.
CT-Visible Microspheres Enable Whole-Body In Vivo Tracking of Injectable Tissue Engineering Scaffolds
[Advanced Healthcare Materials] An injectable tissue engineering scaffold consisting of highly porous microspheres compatible with transplantation of cells was modified to contain the computed tomography contrast agent barium sulphate.
Comparative Performance of scFv-Based Anti-BCMA CAR Formats for Improved T Cell Therapy in Multiple Myeloma
[Cancer Immunology Immunotherapy] CD8TM.41BBIC-based anti-BCMA CAR vectors with either a long linker or a short linker between the light and heavy scFv chain, CD28TM.41BBIC-based and CD28TM.CD28IC-based anti-BCMA CAR vector systems were used in primary human T cells.
Network Meta-Analysis of CAR T-Cell Therapy for the Treatment of 3L+ R/R LBCL After Using Published Comparative Studies
[Expert Review Of Anticancer Therapy] Scientists highlight important differences in clinical outcomes between CAR T-cell therapies. Axi-cel demonstrated improved overall survival compared to tisa-cel and liso-cel, and both axi-cel and liso-cel showed higher response rates compared to tisa-cel.
PolyU Collaborates With Axis Therapeutics to Establish Joint Laboratory for Immunotherapy
[Hong Kong Polytechnic University (EurekAlert!)] The Hong Kong Polytechnic University has entered into a formal collaboration with Axis Therapeutics to foster cancer immunotherapy research and development, with the aim of improving cancer treatment for patients in Hong Kong.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
