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Cell Therapy News
Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Continuously Improving Outcome Over Time after Second Allogeneic Stem Cell Transplantation in Relapsed Acute Myeloid Leukemia: An EBMT Registry Analysis of 1540 Patients
[Blood Cancer Journal] Long-term EBMT registry data were used to provide large scale, up-to-date outcome results and to identify factors for improved outcome
Treatment of Concomitant Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome with Autologous CD19-Targeted CAR T Cells
[Neuron] Scientists detailed the safe application of anti-CD19 CAR T cells for treating concomitant MG/LEMS. After CAR T cell therapy, both patients experienced rapid clinical recovery and regained full mobility.
Biomaterial-Enhanced Treg Cell Immunotherapy: A Promising Approach for Transplant Medicine and Autoimmune Disease Treatment
[Bioactive Materials] The authors introduce strategies based on biomaterial-assisted Treg immunotherapy to enhance transplant medicine and autoimmune treatments.
Recent Trends in 3D Bioprinting Technology for Skeletal Muscle Regeneration
[Acta Biomaterialia] Investigators discuss existing treatment strategies following muscle damage, recent progress in bioprinting techniques, the bioinks used for muscle regeneration, the immunogenicity of scaffold materials, and in vitro and in vivo maturation techniques for 3D bio-printed muscle constructs.
HER2-Targeting CAR-T Cells Show Highly Efficient Anti-Tumor Activity Against Glioblastoma Both In Vitro and In Vivo
[Genes And Immunity] Researchers constructed third-generation CAR-T cells targeting the HER2 antigen in glioblastoma. HER2-CAR-T cells showed effective anti-tumor activity both in vitro and in vivo.
Combination Therapy With Oncolytic Virus and T Cells or mRNA Vaccine Amplifies Antitumor Effects
[Signal Transduction And Targeted Therapy] Combination therapy significantly increased cytokine and chemokine levels within tumors and recruited CD8+ T cells to the TME to trigger antitumor immune responses.
A Case of T Cell Acute Lymphoblastic Leukemia in Retroviral Gene Therapy for ADA-SCID
[Nature Communications] Researchers described a case of gene therapy-related T cell acute lymphoblastic leukemia that developed 4.7 years after treatment. The patient underwent chemotherapy and haploidentical transplantation and is currently in remission.
Space-Made Fibers and Novel Biotech Among Research Returning to Earth after Successful Space Station Mission
[ISS National Laboratory] Research on a novel vision loss therapy and space-manufactured optical fibers were among the nearly 565 pounds of science and technology payloads sponsored by the International Space Station (ISS) National Laboratory that splashed down off the Florida coast Tuesday morning as NASA concluded SpaceX’s 30th Commercial Resupply Services mission.
Placental Circulating T Cells: A Novel, Allogeneic CAR-T Cell Platform with Preserved T Cell Stemness, More Favorable Cytokine Profile, and Durable Efficacy Compared to...
[Journal For Immunotherapy Of Cancer] Investigators compared CAR-T cells generated from healthy adult peripheral blood T cells versus placental circulating T (P-T) cells. CAR-T cells from healthy adult peripheral blood mononuclear cells and P-T cells were generated using the same protocol.
Clonal Relapse Dynamics in Acute Myeloid Leukemia Following Allogeneic Hematopoietic Cell Transplantation
[Blood] Scientists elucidated the molecular architecture and kinetics preceding AML relapse by utilizing error-corrected next-generation sequencing in 74 AML patients relapsing after alloHCT evaluating 140 samples from peripheral blood collected 0.6 to 14 months before relapse.
Outcomes of HLA-Mismatched HSCT With TCRαβ/CD19 Depletion or Post-HSCT Cyclophosphamide for Inborn Errors of Immunity
[Blood] Investigators performed a retrospective multicenter study via the EBMT registry on 306 children with IEI undergoing first transplant between 2010-2019 from an HLA-mismatched donor using TCRαβ or PTCY.
First Fetus-to-Fetus Transplant Demonstrated in Rats
[Nature News] Surgeons in Japan have transplanted kidney tissue from one rat fetus to another, while the recipient was still in its mother's womb. Study lead Takashi Yokoo, a nephrologist at Jikei University School of Medicine in Tokyo, says the surgery is the first step to one day transplanting fetal pig kidneys into human fetuses that develop without functioning kidneys.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
