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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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CANDiT: A Machine Learning Framework for Differentiation Therapy in Colorectal Cancer
[Cell Reports Medicine] Scientists developed CANDiT, a machine learning framework that identifies transcriptomic vulnerabilities for differentiation therapy in colorectal cancer (CRC). A clinical-grade PRKAB1 agonist reactivates lineage programs, dismantles Wnt/YAP-driven stemness, and selectively eliminates CDX2-low CSCs across CRC cell lines, xenografts, and patient-derived organoids
FZD7 Expression Marks Mammary Tumor-Initiating Cells
[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that frizzled class receptor 7 (Fzd7) marks a population of putative tumor-initiating cells and that targeting Fzd7 offers a promising therapeutic strategy for breast cancer.
Endoplasmic Reticulum-Mitochondria Dual-Targeting Nanoplatform Suppresses Cancer Stemness and Enhances Colorectal Cancer Immunotherapy
[Journal of Controlled Release] To counteract stemness-driven immune evasion in colorectal cancer, researchers developed a hyaluronic acid (HA) surface-modified dual-targeting nanoplatform that induces both endoplasmic reticulum stress and mitochondrial dysfunction.
PPARγ, a Key Modulator of Metabolic Reprogramming, Stemness, and Chemoresistance Associated with Retrodifferentiation in Human Hepatocellular Carcinomas
[Cell Death & Disease] By studying metabolic reprogramming associated with human hepatocellular carcinoma cell plasticity, scientists identified an unsuspected role of peroxisome proliferator-activated receptor (PPAR)γ in hepatic CSC phenotype acquisition.
Ginsenoside Rh2 As a Novel PIN1 Inhibitor Disrupting the Cancer Stem Cell-Like Phenotype in Non-Small Cell Lung Cancer
[Journal of Translational Medicine] Scientists investigated the mechanisms by which ginsenoside Rh2 (G-Rh2) targeted CSCs and enhanced the efficacy of gefitinib.
Identification of Novel Phenoxazine-Derived LSD1 Inhibitors Suppressing Gastric Cancer Stemness by β-Catenin Transcriptional Regulation
[Journal of Medicinal Chemistry] Researchers designed and synthesized a novel class of phenoxazine-based LSD1 inhibitors. Mechanistic studies revealed an inhibitor that suppressed the stemness of gastric cancer cells by interrupting the β-catenin-mediated transcriptional program, thereby reducing the expression of stemness-related proteins.
CD271 Targeted Near-Infrared Photoimmunotherapy for Local Depletion of Cancer Stem Cells
[Molecular Pharmaceutics] The efficacy of near-infrared photoimmunotherapy against CD271, which has been reported as a marker of cancer stem cells in various cancers, including head and neck cancers, was confirmed using two different human head and neck cancer cell lines, HPCM2 and HSC-3.
MTA1 Upregulation Enhances Stemness and Chemoresistance of Gastric Cancer Cells
[Translational Oncology] Metastasis-associated protein 1 (MTA1) enhanced chemoresistance and stemness in gastric cancer cells by modulating apoptosis and stemness-related proteins.
Quercetin Suppresses Endometrial Cancer Stem Cells via ERα-mediated Inhibition of STAT3 Signaling
[Discover Oncology] Investigators demonstrated that quercetin targets the stemness of CSCs in an ERα-dependent manner, highlighting its potential as a promising therapeutic agent against CSCs to improve clinical outcomes in endometrial carcinoma.
ONECUT2-Driven Activation of ADAMTS14 Boosts Colorectal Cancer Stemness via Wnt Pathway
[Human Cell] Investigators revealed a novel mechanism by which the ONECUT2/ADAMTS14/Wnt axis regulates the stemness of colorectal cancer cells, providing a potential molecular target for targeted intervention.
The Role of Immune Checkpoints in Modulating Cancer Stem Cells Anti-Tumor Immune Responses: Implications and Perspectives in Cancer Therapy
[Journal of Experimental & Clinical Cancer Research] Scientists summarize the immunomodulatory properties of CSCs and comprehensively discuss the crosstalk between these cells and selected immune checkpoints that are thought to be involved in CSC-mediated immune evasion.
Resveratrol-Mediated Suppression of Glioblastoma and Glioma: Targeting Apoptosis, Differentiation, and Stem Cell Dynamics
[Cancer Cell International] The authors delineate the mechanistic landscape by which resveratrol attenuates glioblastoma (GBM) progression, with emphasis on apoptosis induction, the promotion of differentiation, and the modulation of GBM stem-like cell phenotypes.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
