Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
SATB1 Is a Key Regulator of Quiescence in Stem-Like CD8+ T Cells
[Nature Immunology] Researchers identified the genomic organizer SATB1 as selectively enriched in both TPRO and memory CD8+ T cells. Given its role in promoting quiescence in hematopoietic stem cells, they hypothesized that SATB1 supports CD8+ T cell stemness.
The Bispecific Innate Cell Engager AFM28 Eliminates CD123 Leukemic Stem and Progenitor Cells in AML and MDS
[Nature Communications] The authors described the preclinical efficacy and safety of the bispecific CD123/CD16A innate cell engager “AFM28”, demonstrating superior activity against acute myeloid leukemia and myelodysplastic neoplasms patient-derived leukemic stem and progenitor cells and blasts in vitro compared to an Fc-enhanced CD123-targeting antibody, especially towards CD123low and/or CD64+ leukemic cells.
Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem-Like Cells in Ovarian Cancer
[Advanced Science] Scientists identified an increased expression of peptidylarginine deiminase 1 (PAD1) in ovarian cancer (OC) cells, particularly within the CD133+ subset or cisplatin-resistant cells, which is positively associated with the upregulation of stemness-related markers and maintenance of stemness in OC stem-like cells.
KSRP-Mediated Wnt/β-Catenin Activation Promotes Follicular Thyroid Cancer Progression and Stemness
[British Journal of Cancer] K-homology-type splicing regulatory protein (KSRP) was significantly upregulated in follicular thyroid cancer (FTC) tissues and metastatic cell lines. Functional studies demonstrated that KSRP enhances the invasiveness and stemness of FTC cells.
TLR2 Agonism Suppresses Myeloid Leukemogenesis by Reprogramming Leukemia Stem Cells
[Blood Advances] TLR2 ligands were the only Toll-like family receptors (TLR) agonists capable of extending survival of acute myeloid leukemia-bearing mice through leukemia stem cell reprogramming that elevated MHC class II surface expression and ultimately impaired self-renewal.
Notch3 Mediated TGF‑β1 Activation Enhances Epithelial‑Mesenchymal Transition and Cancer Stemness in Non‑Small Lung Cancer
[International journal of oncology] Investigators demonstrated that Notch3 regulated epithelial‑mesenchymal transition and CSC properties in non‑small cell lung cancer (NSCLC), promoting tumor recurrence and metastasis. Notch3 thus represents a promising therapeutic target and prognostic marker for NSCLC.
Role of CD133 Antibody-Conjugated Nanocarrier in Enhancing the Targetability of Hepatocellular Carcinoma Stem Cells
[Scientific Reports] Researchers aimed at targeting hepatic CSCs with quercetin or kaempferol loaded into poly(lactide-co-glycolide) nanoparticles decorated with CD133 antibody.
Single-Cell Transcriptome Sequencing Reveals Tumor Stem Cells and Their Molecular Characteristics in Intrahepatic Cholangiocarcinoma
[Scientific Reports] The cancer stem cell subpopulation (CXCR4hiBPTFhiE-T) exerts a significant influence on intrahepatic cholangiocarcinoma progression by secreting relevant signaling molecules via the MIF signaling pathway.
Targeting mTOR and Its Associated Signaling to Induce Cell Death in Breast Cancer Stem Cells
[Cell Biology International] Torin-2 treatment of spheroids derived from breast cancer cells suppressed the expression of stem cell marker ALDH. Altogether, the dual inhibition of mTORC1 and mTORC2 by Torin-2 resulted in a more profound antitumor activity.
Advances in Nanomedicine for Targeting Cancer Stem Cells and Overcoming Therapeutic Resistance
[ACS Nano] The authors comprehensively examine advancements in biomaterials, emphasizing advances in nanomedicine design, therapeutic strategies, and persistent challenges in tackling CSC-related resistance.
Genmab Receives FDA Breakthrough Therapy Designation for Rinatabart Sesutecan (Rina-S®) in Advanced Endometrial Cancer (EC)
[Genmab] Genmab announced that the US FDA has granted Breakthrough Therapy Designation to rinatabart sesutecan, an investigational folate receptor alpha-directed, TOPO1-inhibitor antibody-drug conjugate, for the treatment of adult patients with recurrent or progressive endometrial cancer who have disease progression on or following prior treatment with a platinum-containing regimen and a PD-(L)1 therapy.
Role of CD133 Antibody-Conjugated Nanocarrier in Enhancing the Targetability of Hepatocellular Carcinoma Stem Cells
[Scientific Reports] Scientists aimed at targeting hepatic cancer stem cells with quercetin or kaempferol loaded into poly(lactide-co-glycolide) nanoparticles decorated with CD133 antibody.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
