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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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KDM4B/DHX9 Promotes Chemoresistance in Small-Cell Lung Cancer through the MYCN-Driven Signaling Pathway
[Oncogene] Researchers identified KDM4B as a key driver of chemoresistance, with immunohistochemical analysis revealing its elevated expression in chemoresistant tissues from small cell lung cancer patients. KDM4B promoted chemoresistance through the Hedgehog pathway by enhancing cell proliferation and stemness.
New Awards and Publications Showcase Achievements from Staff at the National Comprehensive Cancer Network
[NCCN® (EurekAlert)] The National Comprehensive Cancer Network®(NCCN®) announced several recent external awards and publications honoring the work of NCCN’s dedicated staff. The distinctions focused on scientific research, policy efforts, patient information, and system improvements.
Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal Epithelium
[Cell Death & Disease] Using a Smad4 loss-of-function and β-catenin gain-of-function mouse model, researchers demonstrated that dedifferentiation-derived oncogenic stem cells sustain tumorigenesis more effectively than endogenous mutant stem cells harboring the mutation.
Mesenchymal Stem Cell-Directed Targeted Chemotherapy Primes Drug-Resistant Metastatic Ovarian Tumors for Elimination by Natural Killer Cells
[Molecular Therapy Oncology] Using patient-derived, drug-resistant metastatic ovarian cancer models, investigators showed that exposure to SN38 or 5-FU upregulates NKG2D stress ligands on CSCs, enhancing their susceptibility to NK-mediated cytotoxicity.
Dopamine Abrogates Immunosuppression Mediated by PD-L1 of Cancer Stem Cells in a Preclinical Triple-Negative Breast Cancer Model
[Acta Pharmacologica Sinica] Researchers revealed that the PD-1/PD-L1 pathway predominantly mediates CSC-driven immune evasion, growth, and metastasis in triple-negative breast cancer.
Longitudinal Localization of Leukemic Stem Cells between the Metaphysis and Central Marrow Governs Their Behavior
[Nature Cell Biology] Scientists characterized longitudinal bone marrow niches supporting LSC survival, distinguishing the metaphysis from the central marrow.
The Sleeping Threat: Targeting Cancer Dormancy to Transform Metastasis Therapy
[Nature Reviews Cancer] The authors summarize microenvironmental drivers of dormancy, including the role of niche-derived signals and extracellular matrix composition in maintaining disseminated cancer cell quiescence, as well as the epigenetic and transcriptional programmes, and chromatin remodelling that enforce and sustain dormancy.
Histone Methylation Defines C-Jun/Sox2/Hif1α Axis That Controls Stemness and Tumor Progression in Squamous Cell Carcinoma
[Nature Communications] Investigators showed that the whole-transcriptome profile of CSCs from skin squamous cell carcinoma patients reveals upregulation in expression of genes associated with global hypermethylation, enhanced non-canonical Wnt signaling, and glycolysis, thereby activating the c-Jun/Sox2/Hif1α axis.
HOOK2 Downregulation Compromises the Tumorigenic and Stemness Properties of Ovarian Cancer Cells by Increasing Endoplasmic Reticulum Stress
[Cell Death & Disease] Researchers observed that the decrease in HOOK2, an adaptor protein involved in microtubule transport, diminishes the properties of cancer stem cells in ovarian cancer, possibly due to the increase in cell death specifically found within these stem cells.
CK1α Agonists Attenuate Medulloblastoma Stemness and Relapse Risk
[Cell Death & Disease] The authors tested whether pyrvinium and a brain-permeable derivative, SSTC3, affect stemness and relapse risk in mouse and human-derived SHHα medulloblastoma models.
MMRN1-EGFR Drives Sialylglycan-Siglec Immune Evasion in AML Leukemia Stem Cells
[Cell Stem Cell] Scientists identified multimerin 1 (MMRN1) as being highly and specifically expressed in leukemia stem cells (LSC). They established MMRN1 as a dual-functional target for LSC maintenance and immune evasion and propose that disrupting MMRN1 or EGFR remodels the immunosuppressive tumor microenvironment.
STAT3 Signaling Mediates EGFR-TKI Resistance in Non-Small Cell Lung Cancer by Regulating Stemness Markers and Telomerase, Reversed by Icaritin
[British Journal of Cancer] The authors found that inhibition of the MAPK pathway by EGFR-tyrosine kinase inhibitors triggers the rapid activation of STAT3 in non-small cell lung cancer. RNA-seq analysis and cellular experiments confirmed that STAT3 regulates the expression of stemness markers, which contribute to drug resistance.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
