[Cancer Cell International] Investigators explored recent advances in iron metabolism in CSCs, conventional cancer therapies targeting iron biochemistry, therapeutic resistance in these cells, and potential treatment options that could overcome them.

[Fierce Biotech] With $1.1 billion cash on Madrigal Pharmaceuticals’ balance sheet, CEO Bill Sibold believes the company can “fully resource” the launch of Rezdiffra, the first FDA-approved therapy for fatty liver disease.

[Scientific Reports] The authors evaluated the impact of DBF4 on proliferation, migration, and invasion of HCC cells. RNA sequencing and KEGG pathway enrichment analysis were also conducted to identify potential pathways, which were further validated through WB experiments.

[Liver International] The impact of Thy-1 on the development of SLD and progression to fibrosis was investigated in high-fat diet-induced SLD wild-type and Thy-1-deficient mice.

[Journal Of Cellular Biochemistry] Investigators showed that knockdown of ZNF469 in primary human HSCs impaired proliferation, migration, and collagen production. Conversely, overexpression of ZNF469 in HSCs yielded the opposite results.

[NPJ Regenerative Medicine] The authors highlight three therapies, each utilising a different cell type, at different stages in their clinical translation journey: transplantation of multipotent mesenchymal stromal/signaling cells, hepatocytes, and macrophages.

[American Liver Foundation (PR Newswire)] Winners from the American Liver Foundation's 2024 Liver Health Poster Competition were announced. This competition showcases posters and a brief video created by early career healthcare professionals from across the country on six areas of liver educational focus.

[eLife] The authors demonstrated that loss of the Mirlet7b/Mirlet7c2 cluster in T cells predisposed mice to exaggerated cigarette smoke- or nanosized carbon black-elicited emphysema.

[Inflammation] Investigators observed a significant increase in iron concentration during acute lung injury, accompanied by elevated levels of lipid peroxidation markers such as malonaldehyde and 4-hydroxynonenal.

[Bioscience, Biotechnology, and Biochemistry] Researchers found that Sfrp5 expression in oxLDL-treated human vascular smooth muscle cells (HVSMCs) was downregulated. Sfrp5 overexpression inhibited the viability of HVSMCs induced by oxLDL.

[FASEB Journal] Analysis of genetic markers on E13.5, E16.5, and E19.5 in the rat metrial gland, the entry point of uterine arteries, revealed that trophoblast invasion was associated with downregulation of MYOCARDIN, α-smooth muscle actin, and calponin1, and concomitant upregulation of Smemb in vascular smooth muscle cells.

[Nature Communications] Investigators showed how the post-transcriptional regulatory layer instructed the level of chromatin regulation via miR-144 and its targets to orchestrate chromatin condensation during erythropoiesis.