[Biomaterials Advances] Decellularized extracellular matrix-derived from sheep muscle tendon junction (MTJ) was used to provide a scaffold for the MTJ with the relevant mechanical properties and differentiation cues such as the relase of growth factors.

[Hesperos, Inc.] Hesperos was awarded a $2 million research grant by the National Center for Advancing Translational Sciences in collaboration with the US FDA. The goal of the effort is to develop an advanced testing platform capable of assessing the potency of the Botulinum Toxin without the need for animal testing.

[Stem Cell Research & Therapy] To manufacture hematopoietic organoids, researchers obtained CD34+ hematopoietic stem and progenitor cells from human embryonic stem cells using stepwise induction and immunomagnetic bead-sorting.

[Molecular Biology Reports] Scientists gained further insight into the molecular disruptions in the RB1+/− retinal organoids, they performed a high throughput RNA sequencing analysis.

[Cell Reports] Investigators showed that pluripotent stem cell-derived phosphatase and tensin homolog (PTEN) mutant human neurons, neural precursors, and cortical organoids recapitulated disease-relevant phenotypes, including hypertrophy, electrical hyperactivity, enhanced proliferation, and structural overgrowth.

[Informationsdienst Wissenschaft] Placenta organoids created from cultured human placenta cells have been used to shed light on several types of infection in early pregnancy

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that the T cell lineage protein THEMIS operates as a rheostat which restrain the signaling capacity the inhibitory receptor B- and T-lymphocyte attenuator (BTLA).

[ACS Nano] Scientists presented a well-designed triune nanomodulator, termed ROCA, which demonstrated robust capabilities in tumor epigenetic modulation and immune microenvironment reprogramming for cancer epigenetic immunotherapy.

[National Institutes of Health] The Complement Animal Research In Experimentation Challenge Prize competition offered $1,000,000 in total prize money to diverse teams with ideas for new ways of using New Approach Methodologies to conduct basic research, uncover disease mechanisms, and translate knowledge into products and practice.

[Nature Reviews Immunology] The authors described the contribution of the various atypical chemokine receptors to innate and adaptive immune responses, focussing specifically on recent progress.

[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, researchers identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.

[Emerging Microbes & Infections] Investigators elucidated the antigenic characteristics and immune evasion capability of BA.2.87.1. Our findings revealed that BA.2.87.1 was more susceptible to XBB-induced humoral immunity compared to JN.1.