[Nature Communications] Researchers used intravital pH imaging at single-corneocyte resolution to demonstrate that corneocytes undergo differentiation to develop three distinct zones in the stratum corneum, each with a distinct pH value.

[Scientific Reports] Scientists discovered that TLR adaptor interacting with solute carrier family 15 member 4 on the lysosome (TASL) deficiency hindered the proliferation and migration of keratinocytes by inducing G1/S cell cycle arrest.

[Cell Death Discovery] Investigators evaluated the implication of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) in ultraviolet radiation (UV) B-induced cell death in human diploid dermal fibroblasts, and reported that RIPK3 and MLKL played opposite roles in UVB-induced cell death, in a necroptosis independent pathway.

[Journal Of Investigative Dermatology] Scientists review some of the techniques that have been developed for eliciting cutaneous wounds in the zebrafish, including an economical method they recently developed using a rotary tool that generates consistent and reproducible full-thickness wounds.

[Journal Of Molecular Cell Biology] Using a mouse mammary gland model, investigators delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development.

[PLOS Genetics] Researchers identified Resf1 as a novel metastasis susceptibility gene in ER- breast cancer. Reduction of Resf1 resulted in a significant increase in tumor growth, a shortened overall survival time, and increased incidence and number of lung metastases, consistent with patient data.

[FEBS Journal] Researchers elucidated the role of WDR61 in breast tumor development, and reported that knockdown of WDR61 compromised the proliferation of breast tumor cells with reduced colony-forming capacity.

[Cancer Science] The authors provide a comprehensive review on the clinical features, molecular characteristics, invasion and metastasis patterns, and prognosis of metaplastic breast cancer, as well as recent advancements in treatment strategies.

[Cancer Research] Scientists identified upregulation of the transcriptional corepressor DRAP1 in TNBC, which was closely associated with poor recurrence-free survival in TNBC patients.

[Endocrine] The authors review the current advances and challenges faced by stem cell differentiation into functional β-cells for diabetes treatment.

[Cell Death & Disease] Investigators reported that ubiquitin-protein ligase E3 module N-recognition 5 (UBR5) was a therapeutic target against gemcitabine (GEM) resistance. Further analysis revealed that UBR5 promoted GEM resistance in pancreatic cancer cells by enhancing O-GlcNAcylation-mediated epithelial-mesenchymal transition.

[International Journal Of Biological Macromolecules] Investigators utilized biocompatible copolymers of L-lactide and D,L-lactide to manufacture a biomaterial scaffold with a mesh-like structure via 3D printing technology, providing a material foundation for encapsulating pancreatic islet cells.