Keep Current with the Latest in Cell Biology Research

circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

High Fat Diet Ameliorates Mitochondrial Cardiomyopathy in CHCHD10 Mutant Mice

[EMBO Molecular Medicine] Heterozygous S55L mice were subjected to chronic high-fat diet to decrease insulin sensitivity and glucose uptake and enhance fatty acid utilization in the heart.

Mitochondria Regulate Proliferation in Adult Cardiac Myocytes

[Journal Of Clinical Investigation] Researchers tested whether forced reversal of adult cardiomyocytes back to a fetal glycolytic phenotype would restore proliferative capacity. They deleted Uqcrfs1 in hearts of adult mice.

AML/T Cell Interactomics Uncover Correlates of Patient Outcomes and the Key Role of ICAM1 in T Cell Killing of AML

[Leukemia] Single-cell RNA-seq of primary AML samples and CD4+ T cells before and after their interaction uncovered transcriptional programs that correlate with AML sensitivity or resistance to CD4+ T cell killing.

Role of Umbilical Cord Mesenchymal Stromal Cells in Skin Rejuvenation

[npj Regenerative Medicine] Investigators summarize the characteristics of skin aging and the mechanism of umbilical cord-derived MSCs (UC-MSCs) in skin rejuvenation reported in recent years in order to provide a reference for further research of UC-MSCs to delay skin aging.

Quantitative Proteomics Reveals the Dynamic Proteome Landscape of Zebrafish Embryos during the Maternal-to-Zygotic Transition

[iScience] The authors revealed the expression dynamics of 5,000 proteins across four stages of zebrafish embryos during maternal-to-zygotic transition (MZT), representing one of the most systematic surveys of proteome landscape of the zebrafish embryos during MZT.

A Virus-Inspired Inhalable Liponanogel Induces Potent Antitumor Immunity and Regression in Metastatic Lung Tumors

[Cancer Research] Inspired by the structure of a virus that utilized internal viral proteins to tune the loading and cytosolic delivery of viral nucleic acids, scientists developed a liponanogel-based platform to overcome the delivery challenges of poly(I:C).

Cutibacterium acnes Invades Prostate Epithelial Cells to Induce BRCAness as a Possible Pathogen of Prostate Cancer

[The Prostate] To identify microbiota or pathogens associated with prostate cancer, researchers investigated the transcriptomes of 20 human prostate cancer tissues.

Novel Role of LLGL2 Silencing in Autophagy: Reversing Epithelial-Mesenchymal Transition in Prostate Cancer

[Biological Research] PC3 cells were transfected with siLLGL2 or plasmid LLGL2 and autophagy was examined. Invasion, migration, and wound healing were assessed in PC3 cells under autophagy regulation.

Firms Offering a Fast Track to Publication Target Foreign Applicants to US Medical Residency Programs

[Science Insider] Based in Atlanta, Desai runs a business that offers junior doctors from around the world a chance to beef up their CVs before applying for coveted residency or fellowship positions at hospitals or physician offices in the United States.

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