[Circulation] On the basis of Cas13d homology structure, researchers rationally designed a series of Cas13d variants and obtained a high-precision Cas13d variant that specifically cleaved the MYH7 variant RNAs containing 1 allelic single nucleotide variant.

[American Journal of Hematology] This study included 1115 patients receiving first hematopoietic cell transplantation between 2005 and 2021. Patients were generally balanced for key patient characteristics.

[Inflammopharmacology] Investigators employed the DSS-induced acute colitis mouse model to compare the therapeutic effectiveness of MSCs in pretreated with or without wogonin and further explore the underlying mechanism.

[Nature Communications] Researchers demonstrated that dual inhibition of p53-mediated cell death and distinct activation of the DNA damage repair system upon DNA damage by cytosine base editor or prime editor additively enhanced editing efficiency in hPSCs.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] To identify mechanisms of liver kinase B1 (LKB1)-mediated growth suppression, the authors developed a spheroid-based cell culture assay to study LKB1-dependent growth.

[Oncogene] Investigations of glutamine deprivation on docetaxel-sensitive and -resistant (DR) prostate cancer cells revealed that the DR cell sub-lines were susceptible to Gln deprivation.

[Nature Communications] Researchers used intravital pH imaging at single-corneocyte resolution to demonstrate that corneocytes undergo differentiation to develop three distinct zones in the stratum corneum, each with a distinct pH value.

[Scientific Reports] Scientists discovered that TLR adaptor interacting with solute carrier family 15 member 4 on the lysosome (TASL) deficiency hindered the proliferation and migration of keratinocytes by inducing G1/S cell cycle arrest.

[Cell Death Discovery] Investigators evaluated the implication of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) in ultraviolet radiation (UV) B-induced cell death in human diploid dermal fibroblasts, and reported that RIPK3 and MLKL played opposite roles in UVB-induced cell death, in a necroptosis independent pathway.

[Journal Of Investigative Dermatology] Scientists review some of the techniques that have been developed for eliciting cutaneous wounds in the zebrafish, including an economical method they recently developed using a rotary tool that generates consistent and reproducible full-thickness wounds.

[Journal Of Molecular Cell Biology] Using a mouse mammary gland model, investigators delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development.

[PLOS Genetics] Researchers identified Resf1 as a novel metastasis susceptibility gene in ER- breast cancer. Reduction of Resf1 resulted in a significant increase in tumor growth, a shortened overall survival time, and increased incidence and number of lung metastases, consistent with patient data.