[Archives Of Pharmacal Research] The authors established MCF-10A cell lines incubated with TNF-α to investigate the effects of continuous TNF-α exposure on the phenotypic change of normal mammary epithelial cells.

[Scientific Reports] Researchers evaluated P2X7R and P2X4R expression and morphological changes in the submandibular gland in type 2 diabetes mellitus.

[Cell Death & Disease] Investigators uncovered a new role for bax inhibitor-one, a negative regulator of inositol-requiring enzyme 1 in preserving β-cell health against terminal unfolded protein response (UPR)-induced apoptosis and pyroptosis in the context of supraphysiological loads of insulin production.

[Science Signaling] To better understand the genetic pathways that modulate cancer cell sensitivity to Ras–mitogen-activated protein kinase (MAPK) pathway inhibitors, scientists performed a CRISPR knockout screen with MAPK pathway inhibitors on a colorectal cancer cell line carrying mutant KRAS.

[Cell Death Discovery] HtrA serine protease 1 (HTRA1) was screened out as a colorectal cancer (CRC) progression- and chemoresistance-related gene. Gain- and loss-of-function analyses demonstrated a stimulatory role of HTRA1 on the proliferation of CRC cells.

[Frontiers In Cellular Neuroscience] Scientists demonstrated that cell fate and composition of unguided brain organoids was dictated by culture conditions during embryoid body formation, and that culture conditions at this stage could be optimized to result in the presence of glia-associated proteins and neural network activity as early as three-months in vitro.

[Florida Atlantic University] Three Florida Atlantic University researchers at the forefront of Alzheimer’s disease research have each received a $350,000 grant from the Florida Department of Health’s “Ed and Ethel Moore Alzheimer’s Disease Research Program.

[AC Immune SA] Takeda and AC Immune SA announced a worldwide option and license agreement for AC Immune’s active immunotherapies targeting toxic forms of amyloid beta, including ACI-24.060 for the treatment of Alzheimer’s disease.

[Nature Biotechnology] The authors described a clinically guided method to differentiate and expand IL-15-enhanced allogeneic CAR-NKT cells with high yield and purity.

[Cell Discovery] Investigators reported newly developed anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies (bNAbs) and the follicle-homing receptor CXCR5, termed M10 cells.

[Cancer Science] The authors show edthat CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines.

[Scientific Reports] Investigators isolated exosomes (Exos) from MSCs, and using probe-sonication approach loaded them with vincristine (VCR) sulfate. Using SRB assay, the cytotoxicity of VCR sulfate-Exo was assessed in T47D breast cancer cells, and the results were contrasted with those of free VCR sulfate.