[EMBO Molecular Medicine] Heterozygous S55L mice were subjected to chronic high-fat diet to decrease insulin sensitivity and glucose uptake and enhance fatty acid utilization in the heart.

[Journal Of Clinical Investigation] Researchers tested whether forced reversal of adult cardiomyocytes back to a fetal glycolytic phenotype would restore proliferative capacity. They deleted Uqcrfs1 in hearts of adult mice.

[Leukemia] Single-cell RNA-seq of primary AML samples and CD4+ T cells before and after their interaction uncovered transcriptional programs that correlate with AML sensitivity or resistance to CD4+ T cell killing.

[npj Regenerative Medicine] Investigators summarize the characteristics of skin aging and the mechanism of umbilical cord-derived MSCs (UC-MSCs) in skin rejuvenation reported in recent years in order to provide a reference for further research of UC-MSCs to delay skin aging.

[iScience] The authors revealed the expression dynamics of 5,000 proteins across four stages of zebrafish embryos during maternal-to-zygotic transition (MZT), representing one of the most systematic surveys of proteome landscape of the zebrafish embryos during MZT.

[Cancer Research] Inspired by the structure of a virus that utilized internal viral proteins to tune the loading and cytosolic delivery of viral nucleic acids, scientists developed a liponanogel-based platform to overcome the delivery challenges of poly(I:C).

[The Prostate] To identify microbiota or pathogens associated with prostate cancer, researchers investigated the transcriptomes of 20 human prostate cancer tissues.

[Biological Research] PC3 cells were transfected with siLLGL2 or plasmid LLGL2 and autophagy was examined. Invasion, migration, and wound healing were assessed in PC3 cells under autophagy regulation.

[Science Insider] Based in Atlanta, Desai runs a business that offers junior doctors from around the world a chance to beef up their CVs before applying for coveted residency or fellowship positions at hospitals or physician offices in the United States.

[Nature Communications] Using CRISPR-Cas9 gene editing and confocal microscopy, investigators found that cryopreserved Natural Killer cells largely died via apoptosis initiated by leakage of granzyme B from cytotoxic vesicles.

[Scientific Reports] The authors observed that Me23 significantly decreased the expression of plasma membrane-associated transmembrane protease serine 2 (TMPRSS2) and TMPRSS11D, consequently mitigating the elevated ROS levels induced by SARS-CoV-2.

[Nutrition & Diabetes] A systematic search was conducted in PubMed, Web of Science, Scopus, and Cochrane Library until March 2023 for meta-analyses evaluating the effects of probiotics, prebiotics, and synbiotics on patients with NAFLD.