[Cancer Research] Researchers found that high expression of histone deacetylase (HDAC)3 was associated with poor prognosis in peripheral T cell lymphoma. HDAC3 inhibition suppressed lymphoma growth in immunocompetent mice but not in immunodeficient mice.

[Blood] In neutrophils, monocytes, and natural killer cells from volunteers homozygous for this variant, investigators found a significant downregulation in the expression of leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) when compared with controls without the variant.

[Fate Therapeutics, Inc.] Fate Therapeutics, Inc. announced that the first patient with systemic lupus erythematosus has been treated in the Phase I autoimmunity study of FT819, the company’s off-the-shelf, CD19-targeted chimeric antigen receptor T cell program.

[Scientific Reports] On postoperative day three, histological changes, including chondrocyte death, reduced matrix staining, and superficial fibrillation, were observed. Simultaneously, a compensatory increase in matrix staining was observed.

[Journal Of Clinical Investigation] Researchers reported that Smo-specific ablation in fibroblasts reduced tubular cell apoptosis and inflammation, enhanced perivascular mesenchymal cells activities, and preserved kidney function after acute kidney injury.

[Advanced Materials] Inspired by the natural environment of active proteins, scientists used the cell matrix components hyaluronic acid and protamine to self-assemble with proteins to form a protein-loaded biomimetic core and then incorporated it into ApoE3-reconstituted high-density lipoprotein to form a protein-loaded biomimetic nanocarrier.

[Cell Death & Disease] Researchers demonstrated Teniposide as a potent modulator of the epithelial–mesenchymal transition (EMT) program, specifically through an interferon regulatory factor 7 (IRF7)–N-myc and STAT interactor (NMI) mediated response.

[Oncogene] The authors discuss interconnected epigenetic and metabolic regulatory pathways and then integrate them into an observable cancer metabolism-therapy-resistance axis that may inform clinical intervention.

[Journal Of Clinical Investigation] Scientists reported that the succinate receptor (SUCNR1) was expressed in β-cells and was up-regulated in hyperglycemic states in mice and humans.

[Cancer Research] Researchers used a convergence approach to identify tumor cell and cancer-associated fibroblast interactions through the integration of single-cell data from human tumors with human organoid coculture experiments.

[Journal Of Cell Biology] Through pharmacological and molecular manipulations in vitro, the authors reported that actomyosin-II inactivation diminished the reversible beading process, fostered progressive Ca2+ spreading and thereby increased acute axonal degeneration in stressed axons.

[Communications Biology] Using a multiomic approach, researchers analyzed epigenomic alterations of H3K27ac and global transcriptomic alterations sustained within a hypoxia and normoxia conditioned colorectal cancer cell line at 24 h following initial infection with F. nucleatum.