[Circulation] Researchers used a proteomics screen to identify adducin, an actin capping protein previously not studied in cardiomyocytes, as a regulator of sarcomere disassembly.

[Circulation] Scientists studied the function of homeobox-containing 1 (Hmbox1) in exercise-induced physiological cardiac growth in mice after four weeks of swimming exercise. Hmbox1 expression was then evaluated in human heart samples from deceased patients with myocardial infarction and in the animal cardiac ischemia/reperfusion injury model.

[Arteriosclerosis Thrombosis And Vascular Biology] Challenges both specific, e.g. the lack of specific markers to thoroughly validate human induced pluripotent stem cell-smooth muscle cells (hiPSC-SMC), and general, e.g. a lack of transparency and consensus around methodology in the field, remain. Scientists highlight the recent successes and remaining challenges of the hiPSC-SMC model.

[Utrecht University] A team of researchers from Utrecht University and UMC Utrecht has received a grant of 936,587 euros from the ZonMw Open Competition for research into a serious heart condition that affects both humans and dogs, especially Dobermanns.

[Nature Communications] Investigators discovered that an anticoagulant protein tissue factor pathway inhibitor (TFPI) played an essential role in erythropoiesis via the control of heme biosynthesis in central macrophages.

[Stem Cells Translational Medicine] Scientists investigated the therapeutic effects and underlying mechanisms of bone MSCs transplantation in mouse models of bile duct ligation-induced cholestatic liver fibrosis.

[Nature Communications] Researchers used genomic rearrangements, transgenesis, and targeted mutation to analyze Myc regulation in early mouse embryos and PSCs.

[Targeted Oncology] Kristen Rat Sarcoma viral oncogene (KRAS) mutations are one of the most common oncogenic drivers found in 12–14% of NSCLC and 4% of colorectal cancer tumors.

[Cancer Gene Therapy] The authors investigated the role of the Wnt signaling modulator Dickkopf-1 (DKK1) in the growth and metastatic progression of metastatic CRPC.

[Scientific Reports] Scientists elucidated Twist2 expression and its role in fetal wound healing. Mouse fetuses were surgically wounded, and Twist2 expression in tissue samples from these fetuses were evaluated via in situ hybridization, immunohistochemistry, and reverse transcription-quantitative polymerase chain reaction.

[Cell Reports] Using a ligand-controlled and pancreas-specific knockout in adult mice, researchers demonstrated that Janus tyrosine kinase (JAK1) deficiency prevented the formation of KRASG12D-induced pancreatic tumors. They established that JAK1 was essential for the constitutive activation of STAT3, whose activation is a prominent characteristic of PDAC.

[Oncolytics Biotech, Inc.] Oncolytics Biotech® Inc. will commence enrollment into a new GOBLET study pancreatic cancer cohort following both German regulatory and ethics approvals. This cohort will evaluate pelareorep in combination with modified FOLFIRINOX with or without the PD-L1 immune checkpoint inhibitor atezolizumab in newly diagnosed patients with PDAC.