[Science Insider] Based in Atlanta, Desai runs a business that offers junior doctors from around the world a chance to beef up their CVs before applying for coveted residency or fellowship positions at hospitals or physician offices in the United States.

[Nature Communications] Using CRISPR-Cas9 gene editing and confocal microscopy, investigators found that cryopreserved Natural Killer cells largely died via apoptosis initiated by leakage of granzyme B from cytotoxic vesicles.

[Scientific Reports] The authors observed that Me23 significantly decreased the expression of plasma membrane-associated transmembrane protease serine 2 (TMPRSS2) and TMPRSS11D, consequently mitigating the elevated ROS levels induced by SARS-CoV-2.

[Nutrition & Diabetes] A systematic search was conducted in PubMed, Web of Science, Scopus, and Cochrane Library until March 2023 for meta-analyses evaluating the effects of probiotics, prebiotics, and synbiotics on patients with NAFLD.

[Free Radical Biology And Medicine] Scientists demonstrated that TREM2 was upregulated in murine model with liver fibrosis. Mice lacking TREM2 exhibited reduced phagocytosis activity in macrophages following carbon tetrachloride intoxication.

[Cancer Cell International] Investigators explored recent advances in iron metabolism in CSCs, conventional cancer therapies targeting iron biochemistry, therapeutic resistance in these cells, and potential treatment options that could overcome them.

[Fierce Biotech] With $1.1 billion cash on Madrigal Pharmaceuticals’ balance sheet, CEO Bill Sibold believes the company can “fully resource” the launch of Rezdiffra, the first FDA-approved therapy for fatty liver disease.

[Scientific Reports] The authors evaluated the impact of DBF4 on proliferation, migration, and invasion of HCC cells. RNA sequencing and KEGG pathway enrichment analysis were also conducted to identify potential pathways, which were further validated through WB experiments.

[Liver International] The impact of Thy-1 on the development of SLD and progression to fibrosis was investigated in high-fat diet-induced SLD wild-type and Thy-1-deficient mice.

[Journal Of Cellular Biochemistry] Investigators showed that knockdown of ZNF469 in primary human HSCs impaired proliferation, migration, and collagen production. Conversely, overexpression of ZNF469 in HSCs yielded the opposite results.

[NPJ Regenerative Medicine] The authors highlight three therapies, each utilising a different cell type, at different stages in their clinical translation journey: transplantation of multipotent mesenchymal stromal/signaling cells, hepatocytes, and macrophages.

[American Liver Foundation (PR Newswire)] Winners from the American Liver Foundation's 2024 Liver Health Poster Competition were announced. This competition showcases posters and a brief video created by early career healthcare professionals from across the country on six areas of liver educational focus.