[University of Sheffield] The University of Sheffield will play a central role in the ANGLIA network, which will host a new cutting-edge total-body PET scanner which will transform how a range of diseases are diagnosed and treated.

[Neurological Sciences] The authors delve into the underlying molecular pathways, such as prion-like propagation, cross-seeding, and inflammatory responses that could mediate this interaction, leading to enhanced neurodegeneration in comorbid cases.

[Cell Reports Methods] Scientists took advantage of bioelectric interactions between DNA and embryonic tissue to perform “stereo-tracking,” a developmental targeting strategy that differentially labels cells at different depths within progenitor zones.

[Cell] Researchers showed that decreased expression of mitochondrial electron transport chain (ETC) components protects against capsaicin-induced toxicity and other challenges by mitigating both calcium imbalance and the generation of mitochondrial reactive oxygen species via distinct pathways.

[Nature Immunology] Researchers identified the genomic organizer SATB1 as selectively enriched in both T_PRO and memory CD8⁺ T cells. Given its role in promoting quiescence in hematopoietic stem cells, they hypothesized that SATB1 supports CD8⁺ T cell stemness.

[Nature Communications] The authors described the preclinical efficacy and safety of the bispecific CD123/CD16A innate cell engager “AFM28”, demonstrating superior activity against acute myeloid leukemia and myelodysplastic neoplasms patient-derived leukemic stem and progenitor cells and blasts in vitro compared to an Fc-enhanced CD123-targeting antibody, especially towards CD123^low and/or CD64⁺ leukemic cells.

[Advanced Science] Scientists identified an increased expression of peptidylarginine deiminase 1 (PAD1) in ovarian cancer (OC) cells, particularly within the CD133⁺ subset or cisplatin-resistant cells, which is positively associated with the upregulation of stemness-related markers and maintenance of stemness in OC stem-like cells.

[British Journal of Cancer] K-homology-type splicing regulatory protein (KSRP) was significantly upregulated in follicular thyroid cancer (FTC) tissues and metastatic cell lines. Functional studies demonstrated that KSRP enhances the invasiveness and stemness of FTC cells.

[Blood Advances] TLR2 ligands were the only Toll-like family receptors (TLR) agonists capable of extending survival of acute myeloid leukemia-bearing mice through leukemia stem cell reprogramming that elevated MHC class II surface expression and ultimately impaired self-renewal.

[International journal of oncology] Investigators demonstrated that Notch3 regulated epithelial‑mesenchymal transition and CSC properties in non‑small cell lung cancer (NSCLC), promoting tumor recurrence and metastasis. Notch3 thus represents a promising therapeutic target and prognostic marker for NSCLC.

[Scientific Reports] Researchers aimed at targeting hepatic CSCs with quercetin or kaempferol loaded into poly(lactide-co-glycolide) nanoparticles decorated with CD133 antibody.

[Scientific Reports] The cancer stem cell subpopulation (CXCR4^hiBPTF^hiE-T) exerts a significant influence on intrahepatic cholangiocarcinoma progression by secreting relevant signaling molecules via the MIF signaling pathway.