[Nature Genetics] Researchers combined structural variant discovery and nucleosome occupancy profiling with transcriptomic and immunophenotypic changes in single cells to study intratumoral heterogeneity in complex karyotype AML.

[Nature Communications] Investigators showed that the nuclear lamina exhibited mechanical threshold behavior: once unwrinkled, the nuclear lamina was inextensible.

[Nucleic Acids Research] Researchers elucidated that DNA damage activated Chk2, leading to the phosphorylation of serine 164 on C-terminal binding protein 2 (Ctbp2).

[Signal Transduction and Targeted Therapy] This Phase Ib/II study evaluated the safety and efficacy of combining toripalimab with the gemcitabine plus nab-paclitaxel regimen as first-line treatment for locally advanced or metastatic PDAC and explored predictive biomarkers.

[Oncogene] Scientists demonstrated that suppressing Cripto in vivo significantly decreased invasive cell behavior in aggressive tumors, highlighting a critical oncogenic function of CRIPTO in advanced prostate cancer.

[Scientific Reports] Scientists investigated the role of SLC4A4 and the signaling mechanism underlying its role in modulating the prostate cancer progression.

[Blood] Scientists found that CD33 T cell engaging antibody molecules mediated specific cytotoxicity across AML cell lines, including CD33 or CD70 single-antigen knockout tumors. 7033 CAR-T cells eradicated tumor in an in vivo mixed tumor model of CD70 antigen escape.

[Bone Marrow Transplantation] Scientists conducted a prospective monocentric investigation assessing the use of daratumumab in complications following allo-HSC transplantation. All treated patients, except one, reached transfusion independence with erythropoietin suspension.

[American Journal of Physiology - Cell Physiology] Researchers examined how cohesin mutation impacts hematopoiesis using adult zebrafish that carried heterozygous germline nonsense mutation in the cohesin subunit, rad21 that was orthologous to human RAD21.

[British Journal of Haematology] Using a murine multiple myeloma model (MM) closely resembling human disease, investigators observed that MM progression was associated with anemia and an increase in immature CD71+ erythroid cells, which were characterized by elevated arginase 2 expression.

[Nature Metabolism] Using human induced pluripotent stem cell (SC)-derived islets, the authors showed that IIR knockout (KO) resulted in enhanced SC β cell differentiation and survival. Extended in vitro culture of IIR KO SC β cells led to greatly increased insulin content and glucose-stimulated insulin secretion.

[Cell Death Discovery] While primary islets, the gold standard for in vitro models, have a short culture life of approximately one-two weeks, researchers developed a protocol that employed reformed islets following dispersion coupled with a fine-tuned culture environment.