[Nature Communications] Researchers described the clinical case of an immunosuppressed host in whom inadequate treatment resulted in highly diverse SARS-CoV-2 mutations that threatened the patient’s health due to the development of drug-resistant variants.

[Nature Communications] Scientists increased the number of influenza B viruses (IBV) CD8+ T cell epitopes, and defined IBV-specific CD8+ T cells at cellular and molecular levels, across tissues and age.

[Signal Transduction And Targeted Therapy] Scientists investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (RBD) scaffold protein (3R-NC) adjuvanted with a flagellin protein.

[PLOS One] Investigators highlighted the distinctive roles of L. mucosae and L. helveticus in high-risk human papillomavirus infections, signaling a need for further research to demonstrate the potential clinical implications of cervical microbiota dysbiosis.

[Acta Neuropathologica] Researchers showed that influenza virus entered into the cerebral endothelium and thereby induced influenza-associated encephalopathy. Three-weeks-old young mice were inoculated with influenza A virus.

[Journal Of Cellular Physiology] The authors review the multifaceted functions of B cells in atherosclerosis, with a specific focus on HIV. Unique to atherosclerosis is the pivotal role of natural antibodies, particularly those targeting oxidized epitopes abundant in modified lipoproteins and cellular debris.

[Nature] A strain of highly pathogenic avian influenza has been silently spreading in US cattle for months, according to preliminary analysis of genomic data. The outbreak is likely to have begun when the virus jumped from an infected bird into a cow, probably around late December or early January.

[Nature] The first person to publicly release the genome sequence of the virus that causes COVID-19 — virologist Zhang Yongzhen — appears to have resolved a public dispute with the Shanghai Public Health Clinical Center (SPHCC), Fudan University, that erupted last week.

[ISS National Laboratory] Research on a novel vision loss therapy and space-manufactured optical fibers were among the nearly 565 pounds of science and technology payloads sponsored by the International Space Station (ISS) National Laboratory that splashed down off the Florida coast Tuesday morning as NASA concluded SpaceX’s 30th Commercial Resupply Services mission.

[Journal For Immunotherapy Of Cancer] Investigators compared CAR-T cells generated from healthy adult peripheral blood T cells versus placental circulating T (P-T) cells. CAR-T cells from healthy adult peripheral blood mononuclear cells and P-T cells were generated using the same protocol.

[Small] Investigators introduced a stimulus-responsive glycopeptide hydrogel constructed by oxidized Bletilla striata polysaccharide, gallic acid-grafted ε-Polylysine, and paeoniflorin-loaded micelles, called OBPG&MP.

[Cell Death & Disease] The authors addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies.