[Cellular & Molecular Biology Letters] Researchers focused on investigating the impact of keratinocyte growth factor (KGF) secreted from MSCs on acute lung injury, and clarifying its specific mechanism in regulating the expression of epithelial sodium channel.

[ACS Nano] Researchers applied reversible shearing DNA-based tension probes to assess MSCs’ integrin tension during spreading after biochemical induction to osteogenesis and chondrogenesis.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators utilized enucleated MSC vehicles for the targeted delivery of chimeric antigen receptor (CAR)-encoding plasmid to reprogram glioma-associated microglia/macrophages, thereby achieving CAR-macrophage preparation in vivo.

[Cell Death & Differentiation] Scientists found that glutamine synthetase (GLUL) expression is downregulated in the bone marrow MSCs (BMSCs) of senile osteoporosis patients. Mice with BMSC-specific Glul-knockout exhibits dysplasia of the skull and phalanges due to disordered osteogenic differentiation.

[Advanced Healthcare Materials] The authors investigated the effect of mechanotransduction on human MSCs attached to structural elements of an implant, specifically a titanium truss element.

[Stem Cell Reviews and Reports] Investigators explore the current advancements in photobiomodulation technology and its application in MSC research, with a focus on understanding its mechanisms and therapeutic potential.

[BriaCell Therapeutics] BriaCell Therapeutics announced updated Phase II survival data for its lead immunotherapy candidate, Bria-IMT, in combination with an immune check point inhibitor. The data showed a meaningful survival advantage in heavily pretreated metastatic breast cancer patient subtypes.

[Cellular & Molecular Biology Letters] Scientists identified that the low expression of FERM domain-containing protein 8 (FRMD8) in breast cancer type 1 susceptibility protein (BRCA1)-mutant breast cancer cells enhances the metastatic potential of tumor cells to various organs.

[Cancer Biology & Therapy] Researchers identified the deubiquitinating enzyme USP44 as a contributor to chemoresistance in TNBC and investigated the potential regulatory feedback mechanisms involved.

[British Journal of Cancer] The authors aimed to investigate whether primary tumour resection improves the survival of de novo stage IV breast cancer patients.

[Nature Cancer] Researchers delineated a hypoxia-sensitive, CCL2-dependent pathway recruiting IL-17A-secreting γδ T cells to mouse HR⁺HER2⁻ breast cancer.

[Nature Communications] To evaluate ruxolitinib’s impact on myeloproliferative neoplasm clonal evolution, researchers interrogated a myelofibrosis patient cohort with longitudinal molecular evaluation and discover that ruxolitinib is associated with clonal outgrowth of RAS pathway mutations.