[Experimental & Molecular Medicine] Investigators demonstrated that glutamine endowed PDAC cells with resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through KDM4C-mediated epigenetic regulation of cFLIP.

[Nucleic Acids Research] Scientists revealed a gene activation program that required arginine methylation established by coactivator-associated arginine methyltransferase 1 (CARM1) on a key chromatin remodeler.

[npj Parkinson's Disease] Researchers investigated the mitochondrial role of PARKIN during aging and in response to stress by employing a series of conditional Parkin knockout mice.

[Gut] Scientists generated intestinal epithelium-specific Psen1-deficient, Psen2-deficient and inducible Psen1/Psen2 double-deficient mice to dissect the functional role of presenilins in intestinal homoeostasis.

[EMBO Molecular Medicine] The authors revealed that the epigenetic regulator, chromobox protein homolog 3 (CBX3) antagonized IFNγ signaling in the colon epithelium by transcriptionally repressing two critical IFNγ-responsive genes: STAT1 and CD274.

[Nature Communications] Scientists revealed that intact mitochondrial genome was enriched in serum extracellular vesicles from colon cancer patients and positively correlated with tumor stage.

[Clinical Cancer Research] The anti-multiple myeloma (MM) activity of teclistamab and talquetamab was evaluated in bone marrow (BM) samples from MM patients. T cell phenotype and function were assessed in BM/peripheral blood samples obtained from MM patients who were treated with these bispecific antibodies.

[Journal Of Biological Chemistry] Scientists reported the development of polymer-based anti-human PD-L1 antibody mimetics by attaching the macrocyclic peptide WL12 to a N-(2-hydroxypropyl)methacrylamide copolymer.

[Microbiology Spectrum] Investigators examined a panel of intravenous immunoglobulins manufactured over the past two decades for their capacity to neutralize or enhance Zika virus infection in vitro.

[Scientific Reports] Researchers evaluated the involvement of immunoglobulins and immune complexes in the occurrence of acute kidney injury in visceral leishmaniasis (VL) patients. Fourteen VL patients were evaluated between early treatment and 12 months post-treatment.

[Gene Therapy] Koala Retrovirus-based envelope demonstrated remarkable efficiency in transducing freshly isolated primary human NK cells directly from blood, as well as freshly obtained monocytes, which were differentiated to M1 macrophages as well as B cells from multiple donors, achieving up to 80% reporter gene expression within three days post-transduction.

[Advanced Drug Delivery Reviews] The authors highlight recent pre-clinical and clinical advances in biomaterial-based approaches to target and modulate skin immune signaling at the tissue, cellular, and molecular levels for immunotherapeutic applications.