[Science Insider] Over the past two years, an international group of ethicists, scientists, regulators, and other stakeholders has sought ways to better protect people who join trials as paid, healthy volunteers rather than as patients hoping for an effective treatment.

[British Journal Of Haematology] The authors conducted a pharmacovigilance study to assess the reporting of atrial arrhythmias following CD19-directed CAR-T.

[The American Journal Of Pathology] Detailed cellular and molecular characterization was conducted on MCa-P1362, a newly established mouse model of metastatic breast cancer that is syngeneic in BALB/c mice.

[Acta Biomaterialia] Using a custom mold, skin-derived ECM hydrogels (dECM) were UV crosslinked after diffusion of ruthenium (Ru) to produce a Ru-dECM gradient hydrogel.

[Rochester Institute of Technology] Lamoca’s award will fund a ten-month research experience in the BioIonic Currents Electromagnetic Pulsing Systems Laboratory at the National University of Singapore. His research focuses on age-related neurodegeneration, which can be seen in Alzheimer’s disease, dementia, and other conditions.

[European Heart Journal-Cardiovascular Imaging] Researchers explored associations between ascending aortic hemodynamics, assessed using four-dimensional flow cardiovascular magnetic resonance imaging, and circulating biomarkers in aortic dilation.

[European Journal Of Cell Biology] The authors report what is currently known about these elements in general and their specific interplay in the context of multi- and pluripotent stem cells.

[Cell Death & Disease] Scientists detail the role of different subsets of T cells in liver metastasis (LM) and advances in the management of LM in order to identify potential therapeutic targets for patients with LM.

Investigators explored intratumour heterogeneity and plasticity of cancer cell states in pancreatic dutal adenocarcinoma (PDA) in order to reveal cell state-specific regulators. They analyzed...

[Inflammatory Bowel Diseases] The mRNA and protein expression of oncostatin-M and its receptors, gp130, and several fibrotic and chemotactic factors were studied in mucosal biopsies and isolated human intestinal subepithelial myofibroblasts of patients with inflammatory bowel disease and healthy controls and in a model of human intestinal organoids.

[Nature Communications] Scientists demonstrated the usefulness and necessity of a pooled design to reveal donor iPSC line heterogeneity during macrophage cell differentiation and to model rare WT1 mutation-driven kidney disease with chimeric organoids.

[Cell Stem Cell] Researchers constructed human blood-brain barrier (hBBB) assembloids from brain and blood vessel organoids derived from human pluripotent stem cells. They validated the acquisition of BBB-specific molecular, cellular, transcriptomic, and functional characteristics and uncovered extensive neuro-vascular crosstalk with a spatial pattern within hBBB assembloids.